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Lindsey E. Jones et al. Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma. Neuro-Oncology Advances, 2020. We established robust, versatile, and well-characterized Patient Derived Cells (PDC) of an IDH1-mutant astrocytoma and an IDH1-mutant oligodendroglioma that represents defined evolutionary stages of chemotherapy-induced hypermutation. The PDCs retain tumor subtype defining features over time as well as classic hallmarks of cancer, including anchorage independent growth and cell immortality. The integrated phylogenies composed of PDCs,single-cell-derived PDCs, patient-derived xenografts, and corresponding spatiotemporal tumor tissue samples also provide new insight into the clonality, evolutionary pattern, and immense mutational load of hypermutated IDH mutant gliomas.
Study
EGAS00001003992
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Myeloma RNAseq
Study
EGAS00001003999
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Myeloma WGS
Study
EGAS00001004000
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Tumor-specific expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer
Study
EGAS00001004001
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A Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling
Study
EGAS00001004018
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Whole-genome bisulfite sequencing analysis of low-grade astrocytomas in the ICGC PedBrain Tumor Project
Study
EGAS00001004019
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Uncovering tumor intrinsic and extrinsic factors that regulate hepatocellular carcinoma growth using patient derived xenograft assays
Study
EGAS00001004020
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Cell type-specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics
Study
EGAS00001004053
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Neoadjuvant combination PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable urothelial carcinoma
Study
EGAS00001004074
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Molecular and Clonal Evolution in Recurrent Metastatic Gliosarcoma
Study
EGAS00001004076
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RNA sequencing of CD8 T cells from melanoma patients prior to and during checkpoint immunotherapy and untreated healthy controls
Study
EGAS00001004081
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Phased whole genome sequencing of 10 melanoma samples
Study
EGAS00001004136
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Cancer immune control needs senescence induction by Stat1 dependent cell cycle regulator pathways in tumours
Study
EGAS00001004151
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The role of the mammalian SWI/SNF chromatin remodeling complex in neuroendocrine prostate cancer
Study
EGAS00001004177
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Immuno-genomic landscape of osteosarcoma
Study
EGAS00001004197
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Pancreatic tropism of metastatic renal cell carcinoma
Study
EGAS00001004208
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Analysis of exonic somatic variants in light-chain amyloidosis (ALA) and ALA concomitant with multiple myeloma
Study
EGAS00001004214
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Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes
Study
EGAS00001004235
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Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma
Study
EGAS00001004266
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Mutation signatures in melanocytic nevi reveal characteristics of defective DNA repair
Study
EGAS00001004274
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Multiplexed quantification of four neuroblastoma DNA targets in a single droplet digital PCR reaction
Study
EGAS00001004275
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Molecular profiling of metastatic uveal melanoma
Study
EGAS00001004296
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Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma (arrays set)
Study
EGAS00001004314
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Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.
Study
EGAS00001004320
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Persistent STAG2 mutation in recurrent pediatric glioblastoma
Study
EGAS00001004340
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Comprehensive molecular characterization of brainstem glioma
Study
EGAS00001004341
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Multi-omics profiling of paired primary and recurrent glioblastoma patient tissues
Study
EGAS00001004345
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Molecular subsets in renal cancer determine outcome to checkpoint and angiogenesis blockade
Study
EGAS00001004353
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Sequencing of an adolescent patient with germline RET mutant alveolar rhabdomyosarcoma
Study
EGAS00001004359
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Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome
Study
EGAS00001004366
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Whole genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes
Study
EGAS00001004379
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Bulk RNAseq gene expression of baseline tumors from metastatic urothelial bladder cancer patients (IMvigor210) and metastatic renal cell carcinoma (IMmotion150)
Study
EGAS00001004386
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Accelerated single cell seeding in relapsed multiple myeloma
Study
EGAS00001004404
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The genomic landscape of primary cutaneous anaplastic large cell lymphoma (pcALCL)
Study
EGAS00001004429
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Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma
Study
EGAS00001004430
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ctDNA monitoring using patient-specific sequencing and integration of variant reads - Breast cohort
Study
EGAS00001004446
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ctDNA monitoring using patient-specific sequencing and integration of variant reads - Lung cohort
Study
EGAS00001004447
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CRISPR/Cas9-mediated genome editing of Schistosoma mansoni acetylcholinesterase
Study
EGAS00001004455
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Whole-exome sequencing and microRNA profiling predicted relapse risk of stage I lung adenocarcinomas
Study
EGAS00001004461
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JHMI Cholangiocarcinoma DAC
Dac
EGAC00001000276
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Initial whole genome sequencing of plasma cell neoplasms in First Responders exposed to the World Trade Center attack of September 11, 2001
Study
EGAS00001004467
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Targets of MEK inhibition in DIPG
Study
EGAS00001004495
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Uterine leiomyoma: DNA methylation, chromatin activity and gene expression
Study
EGAS00001004499
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An epigenetic single-cell atlas of IDH-mutant glioma reveals the role of ATRX in shaping tumor composition
Study
EGAS00001004523
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Changes in alternative splicing and associated neo-antigens due to therapy
Study
EGAS00001004524
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Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine
Study
EGAS00001004525
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Transcriptomic analysis of the Phase 3 COMPARZ clinical trial
Study
EGAS00001004534
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Multiomic profiling of early-passage melanoma cell lines.
Study
EGAS00001004536
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Clinical relevance of somatic copy-number alterations in plasma circulating tumor DNA from advanced EGFR-mutated NSCLC patients treated with osimertinib
Study
EGAS00001004539
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Super enhancers define regulatory subtypes and cell identity in neuroblastoma
Study
EGAS00001004551
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MGMT genomic rearrangements contribute to chemotherapy resistance in gliomas
Study
EGAS00001004544
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A Multifactorial Tumor and Immune Cell Profile Determines Response to Immune Checkpoint blockade in Melanoma
Study
EGAS00001004548
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Super enhancers define regulatory subtypes and cell identity in neuroblastoma - RNA-seq
Study
EGAS00001004552
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Clinical Outcomes by Tumor Mutational Burden and Inflammatory Gene Expression With Combined Nivolumab and Ipilimumab or Monotherapy in Advanced Melanoma - CM67 WES
Study
EGAS00001004555
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Regulatory T cell transcriptomic reprogramming characterizes adverse events by checkpoint inhibitors in solid tumors
Study
EGAS00001004694
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Deep MRD profiling defines outcome and unveils different modes of treatment resistance in standard and high risk myeloma
Study
EGAS00001004558
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RNASeq of PDX and CDX tumours treated with ADC
Study
EGAS00001004562
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Clinical Outcomes by Tumor Mutational Burden and Inflammatory Gene Expression With Combined Nivolumab and Ipilimumab or Monotherapy in Advanced Melanoma
Study
EGAS00001004564
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Clinical Outcomes by Tumor Mutational Burden and Inflammatory Gene Expression With Combined Nivolumab and Ipilimumab or Monotherapy in Advanced Melanoma - CM066-WES
Study
EGAS00001004567
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Single cell RNA sequencing of CD19 CAR T-cell infusion products
Study
EGAS00001004576
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Whole Exome Sequences from Iberian Roma samples
Study
EGAS00001004599
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Queensland Melanoma Genomic Biomarker Study
Study
EGAS00001004619
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Mutational landscape of eccrine porocarcinoma (sweat gland tumour)
Study
EGAS00001004632
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RNA sequencing of follicular T cell lymphoma
Study
EGAS00001004646
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Targeted sequencing of Burkitt lymphoma tumour samples from the UK's Haematological Malignancy Research Network
Study
EGAS00001004649
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Cerebrospinal fluid circulating tumour DNA allows the characterisation and monitoring of medulloblastoma
Study
EGAS00001004651
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Tumour gene expression signature in primary melanoma predicts long-term outcomes: A prospective multicentre study
Study
EGAS00001004664
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Lymphoma Group
Dac
EGAC00001001243
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Ultraviolet radiation drives mutations in a subset of mucosal melanomas
Study
EGAS00001004697
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A novel orthotopic patient-derived xenograft model of radiation-induced glioma following medulloblastoma
Study
EGAS00001004709
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STAT5 is a therapeutically targetable vulnerability in cutaneous T-cell lymphoma
Study
EGAS00001004719
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Multi Omics of glioma in the the Chinese Glioma Genome Atlas (CGGA) project
Study
EGAS00001004729
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Identification of rare germline variants in familial multiple myeloma
Study
EGAS00001004734
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Multi-region whole-exome sequencing of 10 neuroblastoma cases
Study
EGAS00001004735
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Small molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma (RNAseq dataset)
Study
EGAS00001004748
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Efficacy of CDK4/6i in preclinical models of malignant pleural mesothelioma
Study
EGAS00001005352
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Investigate the evolutionary trajectories during invasiveness acquisition in early lung adenocarcinoma
Study
EGAS00001004754
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Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
Study
EGAS00001004763
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Metabolic requirements of the metastasis-initiating tumour cell population using oral squamous cell carcinoma (OSCC) as a model system
Study
EGAS00001004765
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Overactivation of the IGF signalling pathway in osteosarcoma
Study
EGAS00001004767
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Rna-Seq Leiomyosarcoma subtypes
Study
EGAS00001004783
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Integrative multi-omic analyses of malignant pleural mesothelioma
Study
EGAS00001004812
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Integrated Genomic and Transcriptomic Analysis Reveals Unique Characteristics of Hepatic Metastases and Pro-metastatic Role of Complement C1q in Pancreatic Ductal Adenocarcinoma
Study
EGAS00001004821
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OpACIN-neo – A Multicenter Phase 2 Study to identify the Optimal neo-Adjuvant Combination scheme of Ipilimumab and Nivolumab – Whole exome sequencing
Study
EGAS00001004832
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Comprehensive genomic and transcriptomic analysis of three synchronous primary tumours and a recurrence from a head and neck cancer patient
Study
EGAS00001004857
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Genomic analysis of a hypermutated gliosarcoma
Study
EGAS00001004864
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Multiregional sequencing of IDH-WT glioblastoma reveals high genetic heterogeneity and a dynamic evolutionary history
Study
EGAS00001005128
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Mutational Landscape of Plasmablastic Lymphoma
Study
EGAS00001004906
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ChIP-seq of plasma cell-free nucleosomes identifies gene expression programs of the cells-of-origin
Study
EGAS00001004913
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Selective Elimination of Immunosuppressive T cells in Patients with Multiple Myeloma
Study
EGAS00001004915
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Splicing patterns in SF3B1 mutated uveal melanoma generate shared immunogenic tumor-specific neo-epitopes
Study
EGAS00001005226
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Tissue and plasma RNA from esophageal cancer and precursor lesions
Study
EGAS00001004939
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Genomic insights into the pathogenesis of Epstein-Barr virus-associated diffuse large B-cell lymphoma by whole-genome and targeted amplicon-based sequencing
Study
EGAS00001004941
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CASCADE metastatic melanoma study
Study
EGAS00001004950
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Cell-free DNA TAPS for early cancer detection
Study
EGAS00001004962
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Assessment of cannabidiol and Δ9-tetrahydrocannabiol in mouse models of medulloblastoma
Study
EGAS00001004963
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Evolutionary dynamics of neuroblastoma
Study
EGAS00001004990
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Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma
Study
EGAS00001005023
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Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity through a pathogenic lipid metabolism-mTOR circuit
Study
EGAS00001005053
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Genetic analysis of HLA and immune escape genes in Diffuse Large B-cell Lymphoma
Study
EGAS00001005054