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Lindsey E. Jones et al. Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma. Neuro-Oncology Advances, 2020. We established robust, versatile, and well-characterized Patient Derived Cells (PDC) of an IDH1-mutant astrocytoma and an IDH1-mutant oligodendroglioma that represents defined evolutionary stages of chemotherapy-induced hypermutation. The PDCs retain tumor subtype defining features over time as well as classic hallmarks of cancer, including anchorage independent growth and cell immortality. The integrated phylogenies composed of PDCs,single-cell-derived PDCs, patient-derived xenografts, and corresponding spatiotemporal tumor tissue samples also provide new insight into the clonality, evolutionary pattern, and immense mutational load of hypermutated IDH mutant gliomas.
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EGAS00001003992
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Myeloma RNAseq
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EGAS00001003999
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Myeloma WGS
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EGAS00001004000
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Tumor-specific expression of let-7i and miR-192 is associated with resistance to cisplatin-based chemoradiotherapy in patients with larynx and hypopharynx cancer
Study
EGAS00001004001
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A Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling
Study
EGAS00001004018
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Whole-genome bisulfite sequencing analysis of low-grade astrocytomas in the ICGC PedBrain Tumor Project
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EGAS00001004019
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Uncovering tumor intrinsic and extrinsic factors that regulate hepatocellular carcinoma growth using patient derived xenograft assays
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EGAS00001004020
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Cell type-specific transcriptomics of esophageal adenocarcinoma as a scalable alternative for single cell transcriptomics
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EGAS00001004053
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Neoadjuvant combination PD-L1 plus CTLA-4 blockade in patients with cisplatin-ineligible operable urothelial carcinoma
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EGAS00001004074
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Molecular and Clonal Evolution in Recurrent Metastatic Gliosarcoma
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EGAS00001004076
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RNA sequencing of CD8 T cells from melanoma patients prior to and during checkpoint immunotherapy and untreated healthy controls
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EGAS00001004081
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Phased whole genome sequencing of 10 melanoma samples
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EGAS00001004136
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Cancer immune control needs senescence induction by Stat1 dependent cell cycle regulator pathways in tumours
Study
EGAS00001004151
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The role of the mammalian SWI/SNF chromatin remodeling complex in neuroendocrine prostate cancer
Study
EGAS00001004177
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Immuno-genomic landscape of osteosarcoma
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EGAS00001004197
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Pancreatic tropism of metastatic renal cell carcinoma
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EGAS00001004208
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Analysis of exonic somatic variants in light-chain amyloidosis (ALA) and ALA concomitant with multiple myeloma
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EGAS00001004214
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Exome sequencing of familial high-grade serous ovarian carcinoma reveals heterogeneity for rare candidate susceptibility genes
Study
EGAS00001004235
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Short and long-read genome sequencing methodologies for somatic variant detection; genomic analysis of a patient with diffuse large B-cell lymphoma
Study
EGAS00001004266
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Mutation signatures in melanocytic nevi reveal characteristics of defective DNA repair
Study
EGAS00001004274
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Multiplexed quantification of four neuroblastoma DNA targets in a single droplet digital PCR reaction
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EGAS00001004275
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Molecular profiling of metastatic uveal melanoma
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EGAS00001004296
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Circulating tumor cells for comprehensive and multiregional non-invasive genetic characterization of multiple myeloma (arrays set)
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EGAS00001004314
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Multiregion Whole-Exome Sequencing Uncovers the Genetic Evolution and Mutational Heterogeneity of Early-Stage Metastatic Melanoma.
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EGAS00001004320
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Persistent STAG2 mutation in recurrent pediatric glioblastoma
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EGAS00001004340
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Comprehensive molecular characterization of brainstem glioma
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EGAS00001004341
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Multi-omics profiling of paired primary and recurrent glioblastoma patient tissues
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EGAS00001004345
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Molecular subsets in renal cancer determine outcome to checkpoint and angiogenesis blockade
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EGAS00001004353
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Sequencing of an adolescent patient with germline RET mutant alveolar rhabdomyosarcoma
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EGAS00001004359
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Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome
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EGAS00001004366
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Whole genome sequencing of glioblastoma reveals enrichment of non-coding constraint mutations in known and novel genes
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EGAS00001004379
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Bulk RNAseq gene expression of baseline tumors from metastatic urothelial bladder cancer patients (IMvigor210) and metastatic renal cell carcinoma (IMmotion150)
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EGAS00001004386
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Accelerated single cell seeding in relapsed multiple myeloma
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EGAS00001004404
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The genomic landscape of primary cutaneous anaplastic large cell lymphoma (pcALCL)
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EGAS00001004429
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Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma
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EGAS00001004430
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ctDNA monitoring using patient-specific sequencing and integration of variant reads - Breast cohort
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EGAS00001004446
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ctDNA monitoring using patient-specific sequencing and integration of variant reads - Lung cohort
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EGAS00001004447
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CRISPR/Cas9-mediated genome editing of Schistosoma mansoni acetylcholinesterase
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EGAS00001004455
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Whole-exome sequencing and microRNA profiling predicted relapse risk of stage I lung adenocarcinomas
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EGAS00001004461
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JHMI Cholangiocarcinoma DAC
Dac
EGAC00001000276
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Initial whole genome sequencing of plasma cell neoplasms in First Responders exposed to the World Trade Center attack of September 11, 2001
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EGAS00001004467
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Targets of MEK inhibition in DIPG
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EGAS00001004495
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Uterine leiomyoma: DNA methylation, chromatin activity and gene expression
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EGAS00001004499
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An epigenetic single-cell atlas of IDH-mutant glioma reveals the role of ATRX in shaping tumor composition
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EGAS00001004523
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Changes in alternative splicing and associated neo-antigens due to therapy
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EGAS00001004524
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Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine
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EGAS00001004525
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Transcriptomic analysis of the Phase 3 COMPARZ clinical trial
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EGAS00001004534
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Multiomic profiling of early-passage melanoma cell lines.
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EGAS00001004536
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Clinical relevance of somatic copy-number alterations in plasma circulating tumor DNA from advanced EGFR-mutated NSCLC patients treated with osimertinib
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EGAS00001004539
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Super enhancers define regulatory subtypes and cell identity in neuroblastoma
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EGAS00001004551