Genomic landscape and PD-1 blockade in Natural-killer/T cell lymphoma
Natural killer/T-cell lymphoma (NKTL) is an aggressive malignancy with a predilection for Asian, Mexican and South American populations. With the exception of Japan, it is the most common mature T-cell lymphoma in Asia. NKTL presents as extranodal disease and mostly affects the upper aerodigestive tract. Neoplastic cells are invariably infected by the Epstein-Barr virus (EBV) and characterized by a cytotoxic phenotype. The genetic landscape of NKTL has been recently unraveled by discoveries describing recurring mutations altering the JAK-STAT pathway, epigenetic modifiers, the DDX3X gene and genetic predisposition in the HLA-DPB1 gene.The genomic landscape of NKTL has been interrogated by whole-exome sequencing, targeted sequencing and single nucleotide polymorphism arrays, but has yet been studied with whole-genome sequencing (WGS). In this study, we will use a combination of WGS, targeted-capture sequencing (TCS) and RNA sequencing data to explore the genetic landscape and its relevance to immunotherapy in NKTL
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001003271 | Illumina HiSeq 2000 | 102 | |
EGAD00001004140 | HiSeq X Ten Illumina HiSeq 2000 Illumina NovaSeq 6000 | 34 | |
EGAD00001005230 | HiSeq X Ten Illumina HiSeq 2000 Illumina HiSeq 2500 | 36 | |
EGAD00001005231 | HiSeq X Ten Illumina HiSeq 2000 | 120 | |
EGAD00001005303 | Illumina NovaSeq 6000 | 214 |
Publications | Citations |
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Whole-genome sequencing identifies responders to Pembrolizumab in relapse/refractory natural-killer/T cell lymphoma.
Leukemia 34: 2020 3413-3419 |
38 |
Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression.
Genome Med 16: 2024 48 |
0 |