Multi-omics of Richter syndrome
Richter syndrome (RS) is the aggressive transformation of Chronic Lymphocytic Leukemia, mostly with Diffuse Large B-Cell Lymphoma histology. While histologically similar, RS and de novo DLBCLs present with different clinical courses. We characterized the RS epigenome by combining genome-wide DNA methylation with transcriptome-sequencing on a large RS cohort.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001007922 | Illumina HiSeq 4000 | 77 | |
EGAD00001009509 | Illumina MiSeq | 58 | |
EGAD00010002194 | Illumina EPIC microarray | 90 |
Publications | Citations |
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In Vivo Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities.
Blood Cancer Discov 4: 2023 150-169 |
7 |
Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome.
Nat Med 29: 2023 158-169 |
21 |
Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis.
Nat Commun 14: 2023 309 |
11 |
ZNF683 marks a CD8<sup>+</sup> T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome.
Cancer Cell 41: 2023 1803-1816.e8 |
10 |