Multi-region whole-exome sequencing of 10 neuroblastoma cases
To investigate intratumour heterogeneity and to better understand tumour evolution in neuroblastoma, we have performed a multi-region whole-exome sequencing on a total of 51 spatially separated tumor samples from 9 primary neuroblastomas (2 low-risk, 1 intermediate-risk and 6 high-risk) and 1 relapsed neuroblastoma. We also assessed the impact of chemotherapy on the clonal expansion by sequencing tumour regions from one medium risk and one high-risk tumour for which we had matched samples obtained at diagnosis and after chemotherapy.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001008020 | Illumina HiSeq 4000 | 61 | |
EGAD00001008133 | Illumina HiSeq 4000 | 50 | |
EGAD00001008156 | Illumina HiSeq 4000 | 141 | |
EGAD00010002225 | Cytoscan HD | 3 |
Publications | Citations |
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Spatial and temporal intratumour heterogeneity has potential consequences for single biopsy-based neuroblastoma treatment decisions.
Nat Commun 12: 2021 6804 |
34 |