RNA-seq, WGS and WES of Hepatocellular carcinomas, enriched in fibrolamellar carcinomas
DNAJB1-PRKACA fusion is a specific driver event in fibrolamellar carcinoma (FLC), a rare subtype of hepatocellular carcinoma (HCC) occurring in adolescents and young adults. In older patients, molecular determinants of HCC with mixed histological features of HCC and FLC (mixed-FLC/HCC) remain to be discovered.This study aims to molecularly caracterize mixed fibrolamellar hepatocellular carcinoma (mixed FLC/HCC) within the molecular liver tumors diversity, in respect of pure FLC and different HCC subtypes. This study reunites WGS data (n=3, Tumoral/Non-Tumoral pairs), WES data (n=43, Tumoral/Non-Tumoral pairs) and RNAseq data (n=66, Tumoral only). On a trascriptomic level, most of the mixed-FLC/HCC RNAseq clustered in a robust subgroup of tumors all showing mutation or translocation inactivating BAP1 that codes for the BRCA1 associated protein-1.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
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EGAD00001005308 | Illumina HiSeq 2000 Illumina HiSeq 4000 | 112 |
Publications | Citations |
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BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
J Hepatol 72: 2020 924-936 |
26 |
Corrigendum to: "BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA" [J Hepatol (2020) 1-13].
J Hepatol 73: 2020 225-226 |
0 |
Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma.
Gut 71: 2022 616-626 |
79 |
Preneoplastic liver colonization by 11p15.5 altered mosaic cells in young children with hepatoblastoma.
Nat Commun 14: 2023 7122 |
0 |