Lothian Birth Cohort 1921 whole genome sequencing study

297 members of the Lothian Birth Cohort 1921 (LBC1921) were sequenced using the Illumina HiSeq X platform. The LBC1921 are a relatively healthy cohort of 550 individuals who underwent cognitive and medical testing at a mean age of 79.1 (SD=0.6) years. They have since undergone four further waves of testing, approximately three years apart.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001005477	LBC1921 and LBC1936 GVCFs called with GATK's HaplotypeCaller were combined and subject to variant quality score recalibration. This VCF contains the subset of samples (n = 296) from the LBC1921 cohort.	Illumina HiSeq X Ten	296
EGAD00001006416	297 members of the LBC1921 were sequenced using the Illumina HiSeq X platform. This dataset contains the gvcfs.	Illumina HiSeq X Ten	297
EGAD00001008775	297 members of the LBC1921 were sequenced using the Illumina HiSeq X platform. This dataset contains the fastq files.	Illumina HiSeq X Ten	297

Publications	Citations
Increased ultra-rare variant load in an isolated Scottish population impacts exonic and regulatory regions. Halachev M, Meynert A, Taylor MS, Vitart V, Kerr SM, Klaric L, S. G. P. Consortium, Aitman TJ, Haley CS, Prendergast JG, Pugh C, Hume DA, Harris SE, Liewald DC, Deary IJ, Semple CA, Wilson JF. PLoS Genet 15: 2019 e1008480	15
Using regulatory variants to detect gene-gene interactions identifies networks of genes linked to cell immortalisation. Wragg D, Liu Q, Lin Z, Riggio V, Pugh CA, Beveridge AJ, Brown H, Hume DA, Harris SE, Deary IJ, Tenesa A, Prendergast JGD. Nat Commun 11: 2020 343	5