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Genomic profiling of ovarian adult type granulosa cell tumors

To investigate the genomic landscape of primary and recurrent ovarian adult type granulosa cell tumors, we first identified an exploratory cohort comprised of cryopreserved surgical biopsies from 24 patients (primary, n = 8; recurrent, n = 16) with 20 having matched normal tissue or peripheral blood samples. We performed whole exome sequencing (WES) on these tumor samples at 200X target coverage (mean 226; range 165-296) and also performed WES on the available normal samples. In addition, we performed cancer gene panel sequencing using the T200.1 hybrid capture platform on FFPE tissue from 55 additional patients (primary, n = 27; recurrent, n = 28), of which we sequenced matched normal tissue for a total of 44.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003961 Illumina HiSeq 2000 44
EGAD00001004091 Illumina HiSeq 2000 99
Publications Citations
KMT2D/MLL2 inactivation is associated with recurrence in adult-type granulosa cell tumors of the ovary.
Nat Commun 9: 2018 2496
26