5727 results for "canc*"

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• Cancer Genomics of the Kidney - Targeted Sequencing

  Dac EGAC00001003091

• RNAseq analysis on metastatic Colorectal Cancer xenografts samples

  Dac EGAC00001003125

• Early on-treatment changes in circulating tumor DNA fraction and response to enzalutamide or abiraterone in metastatic castration-resistant prostate cancer - Data Access Committee

  Dac EGAC00001003128

• Netherlands Cancer Institute (NKI) - Beatriz Carvalho group

  Dac EGAC00001003134

• DAC for ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA

  Dac EGAC00001003141

• TCR sequencing of TIL in breast cancer data access committee

  Dac EGAC00001003173

• Netherlands Cancer Institute (NKI) - Wilbert Zwart Group

  Dac EGAC00001003257

• Cancer Genome Database Data Access Committee (CGDB_DAC)

  Dac EGAC01000000002

• Cancer Genomics Project DBA Data Access Committee

  Dac EGAC01000000005

• Circulating tumor cells Exome sequencing from breast cancer

  Single cell technologies allow interrogating the extent of tumor heterogeneity, providing novel insights into tumor evolution and treatment resistance mechanisms. Here, we investigated the level of genetic heterogeneity among circulating tumor cells (CTCs) at the single nucleotide variation and copy number aberration (CNA) levels and compared it to synchronous matched primary tumor/metastatic lesion from 3 metastatic breast cancer patients with triple-negative (TNBC), HER2-positive (HER2+) and estrogen-receptor-positive (ER+) tumors. Whole exome sequencing was performed on 3 synchronous bulk tumor tissue and 21 single/pooled CTC samples. When comparing bulk tissue with CTCs from the same patient, we found similar CNA profiles and the same patient-specific driver mutations for the HER2+ and TNBC tumors. Different CNA profiles and driver mutations were found for the ER+ tumor, with two distinct clones being identified in the CTCs, one harboring an activating ESR1 mutation, the other one bearing a TP53 mutation. These data suggest that tumor tissue and CTCs provide in a subset of patients complementary clinically relevant information to map tumor heterogeneity and monitor tumor evolution. Further validation is needed.

  Study EGAS00001005228