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Fastq files from target enrichment

Fastq files generated during target sequencing of 10MB genomic region surrounding top hits in GWAS in a subset of 86 individuals in case families. Paired end sequencing performed on Illumina NextSeq.

Request Access

Data Access Agreement for dataset published with study The Genetic Basis of Preeclampsia in an Andean Population Adapted to High Altitude.

DATA ACCESS AGREEMENT These terms and conditions govern access to the managed access datasets (details of which are set out in Appendix I) to which the User Institution has requested access. The User Institution agrees to be bound by these terms and conditions. Definitions Authorised Personnel: The individuals at the User Institution to whom Data Access Committee for study Genetics of Preeclampsia at High Altitudes grants access to the Data. This includes the User, the individuals listed in Appendix II and any other individuals for whom the User Institution subsequently requests access to the Data. Details of the initial Authorised Personnel are set out in Appendix II. Data: The managed access datasets to which the User Institution has requested access. Data Producers: Data Access Committee for study Genetics of Preeclampsia at High Altitudes and the collaborators listed in Appendix I responsible for the development, organisation, and oversight of these Data. External Collaborator: A collaborator of the User, working for an institution other than the User Institution. Project: The project for which the User Institution has requested access to these Data. A description of the Project is set out in Appendix II. Publications: Includes, without limitation, articles published in print journals, electronic journals, reviews, books, posters and other written and verbal presentations of research. Research Participant: An individual whose data form part of these Data. Research Purposes: Shall mean research that is seeking to advance the understanding of genetics and genomics, including the treatment of disorders, and work on statistical methods that may be applied to such research. User: The principal investigator for the Project. User Institution(s): The Institution that has requested access to the Data. 1. The User Institution agrees to only use these Data for the purpose of the Project (described in Appendix II) and only for Research Purposes. The User Institution further agrees that it will only use these Data for Research Purposes which are within the limitations (if any) set out in Appendix I. 2. The User Institution agrees to preserve, at all times, the confidentiality of these Data. In particular, it undertakes not to use, or attempt to use these Data to compromise or otherwise infringe the confidentiality of information on Research Participants. Without prejudice to the generality of the foregoing, the User Institution agrees to use at least the measures set out in Appendix I to protect these Data. 3. The User Institution agrees to protect the confidentiality of Research Participants in any research papers or publications that they prepare by taking all reasonable care to limit the possibility of identification. 4. The User Institution agrees not to link or combine these Data to other information or archived data available in a way that could re-identify the Research Participants, even if access to that data has been formally granted to the User Institution or is freely available without restriction. 5. The User Institution agrees only to transfer or disclose these Data, in whole or part, or any material derived from these Data, to the Authorised Personnel. Should the User Institution wish to share these Data with an External Collaborator, the External Collaborator must complete a separate application for access to these Data. 6. The User Institution agrees that the Data Producers, and all other parties involved in the creation, funding or protection of these Data: a) make no warranty or representation, express or implied as to the accuracy, quality or comprehensiveness of these Data; b) exclude to the fullest extent permitted by law all liability for actions, claims, proceedings, demands, losses (including but not limited to loss of profit), costs, awards damages and payments made by the Recipient that may arise (whether directly or indirectly) in any way whatsoever from the Recipient’s use of these Data or from the unavailability of, or break in access to, these Data for whatever reason and; c) bear no responsibility for the further analysis or interpretation of these Data. 7. The User Institution agrees to follow the Fort Lauderdale Guidelines (http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtd003207.pdf ) and the Toronto Statement (http://www.nature.com/nature/journal/v461/n7261/full/461168a.html). This includes but is not limited to recognising the contribution of the Data Producers and including a proper acknowledgement in all reports or publications resulting from the use of these Data. 8. The User Institution agrees to follow the Publication Policy in Appendix III. This includes respecting the moratorium period for the Data Producers to publish the first peer-reviewed report describing and analysing these Data. 9. The User Institution agrees not to make intellectual property claims on these Data and not to use intellectual property protection in ways that would prevent or block access to, or use of, any element of these Data, or conclusion drawn directly from these Data. 10. The User Institution can elect to perform further research that would add intellectual and resource capital to these data and decide to obtain intellectual property rights on these downstream discoveries. In this case, the User Institution agrees to implement licensing policies that will not obstruct further research and to follow the U.S. National Institutes of Health Best Practices for the Licensing of Genomic Inventions (2005) (https://www.icgc.org/files/daco/NIH_BestPracticesLicensingGenomicInventions_2005_en.pdf ) in conformity with the Organisation for Economic Co-operation and Development Guidelines for the Licensing of the Genetic Inventions (2006) (http://www.oecd.org/science/biotech/36198812.pdf ). 11. The User Institution agrees to destroy/discard the Data held, once it is no longer used for the Project, unless obliged to retain the data for archival purposes in conformity with audit or legal requirements. 12. The User Institution will notify Data Access Committee for study Genetics of Preeclampsia at High Altitudes within 30 days of any changes or departures of Authorised Personnel. 13. The User Institution will notify Data Access Committee for study Genetics of Preeclampsia at High Altitudes prior to any significant changes to the protocol for the Project. 14. The User Institution will notify Data Access Committee for study Genetics of Preeclampsia at High Altitudes as soon as it becomes aware of a breach of the terms or conditions of this agreement. 15. Data Access Committee for study Genetics of Preeclampsia at High Altitudes may terminate this agreement by written notice to the User Institution. If this agreement terminates for any reason, the User Institution will be required to destroy any Data held, including copies and backup copies. This clause does not prevent the User Institution from retaining these data for archival purpose in conformity with audit or legal requirements. 16. The User Institution accepts that it may be necessary for the Data Producers to alter the terms of this agreement from time to time. As an example, this may include specific provisions relating to the Data required by Data Producers other than those stated by the Data Access Committee for study Genetics of Preeclampsia at High Altitudes. In the event that changes are required, the Data Producers or their appointed agent will contact the User Institution to inform it of the changes and the User Institution may elect to accept the changes or terminate the agreement. 17. If requested, the User Institution will allow data security and management documentation to be inspected to verify that it is complying with the terms of this agreement. 18. The User Institution agrees to distribute a copy of these terms to the Authorised Personnel. The User Institution will procure that the Authorised Personnel comply with the terms of this agreement. 19. This agreement (and any dispute, controversy, proceedings or claim of whatever nature arising out of this agreement or its formation) shall be construed, interpreted and governed by the laws of England and Wales and shall be subject to the exclusive jurisdiction of the English courts. 20. The Data were contributed by members of the Research Community with the objective of improving health. If results arising from the Recipient and the Recipient Institution use of the Data could provide health solutions for the benefit of people in the developing world, the Recipient and the Recipient Institution agree to offer non-exclusive licenses to use such results to low income and low-middle income countries (as defined by the World Bank) promptly on request. Agreed for User Institution Signature: Name: Title: Date: Principal Investigator I confirm that I have read and understood this Agreement. Signature: Name: Title: Date: Agreed for Data Access Committee for study Genetics of Preeclampsia at High Altitudes Signature: Name: Title: Date: APPENDIX I – DATASET DETAILS APPENDIX II ––PROJECT DETAILS APPENDIX III –– PUBLICATION POLICY APPENDIX I – DATASET DETAILS Dataset reference (EGA study ID and Dataset Details) EGAS00001004625 Name of project that created the dataset • Investigating the Genetic Basis of Preeclampsia in Populations Adapted to High Altitude • Population and Functional Genomics of the Americas Names of other data producers/collaborators • Stanford University, California, USA • Laboratorio Nacional de Genómica para la Biodiversidad, Unidad de Genómica Avanzada (UGA-LANGEBIO), CINVESTAV, Guanajuato, Mexico • Universidad Peruana Cayetano Heredia, Lima, Peru • Univrsidad del Altiplano, Puno, Peru • Hospital Regional Manuel Nuñez Butrón, Puno, Peru • Arizona State University, Arizona, USA Specific limitations on areas of research This dataset is limited to research areas investigating the genetic basis of preeclampsia and related hypertensive pregnancy disorders; as well as efforts to identify or develop modes of diagnosis and/or treatment. Requestors must demonstrate that their proposed project relates to these research areas. A subset of the samples (labeled as UNA) were collected as population reference samples and thus can be used as controls in future association studies of other traits or as reference panel for population genetics studies (as opposed to the remaining samples of the cohort that are limited in usage as detailed above). Minimum protection measures required File access: Data can be held in unencrypted files on an institutional compute system, with Unix user group read/write access for one or more appropriate groups but not Unix world read/write access behind a secure firewall. Laptops holding these data should have password protected logins and screenlocks (set to lock after 5 min of inactivity). If held on USB keys or other portable hard drives, the data must be encrypted. APPENDIX II – PROJECT DETAILS (to be completed by the Requestor) Details of dataset requested i.e., EGA study and Dataset Accession Number Brief abstract of the Project in which the Data will be used (500 words max) All Individuals who the User Institution to be named as registered users Name of Registered User Email Job Title Supervisor* All Individuals that should have an account created at the EGA Name of Registered User Email Job Title APPENDIX III – PUBLICATION POLICY The Data Producers intend to publish the results of their analysis of this dataset and do not consider its deposition into public databases to be the equivalent of such publications. The Data Producers anticipate that the dataset could be useful to other qualified researchers for a variety of purposes. However, some areas of work are subject to a publication moratorium. The publication moratorium covers any publications (including oral communications) that describe the use of the dataset. For research papers, submission for publication should not occur until 12 months after these data were first made available on the relevant hosting database, unless the Data Producers and Data Access Committee for study Genetics of Preeclampsia at High Altitudes have provided written consent to earlier submission. In any publications based on these data, please describe how the data can be accessed, including the name of the hosting database (e.g., The European Genome-phenome Archive at the European Bioinformatics Institute) and its accession numbers (e.g., EGAS00000000029), and acknowledge its use in a form agreed by the User Institution with Data Access Committee for study Genetics of Preeclampsia at High Altitudes.

Studies are experimental investigations of a particular phenomenon, e.g., case-control studies on a particular trait or cancer research projects reporting matching cancer normal genomes from patients.

Study ID Study Title Study Type
EGAS00001004625 Population Genomics

This table displays only public information pertaining to the files in the dataset. If you wish to access this dataset, please submit a request. If you already have access to these data files, please consult the download documentation.

ID File Type Size Located in
EGAF00005208382 fastq.gz 73.4 MB
EGAF00005208383 fastq.gz 77.0 MB
EGAF00005208384 fastq.gz 253.0 MB
EGAF00005208385 fastq.gz 267.3 MB
EGAF00005329648 fastq.gz 21.7 MB
EGAF00005329649 fastq.gz 23.5 MB
EGAF00005329650 fastq.gz 1.2 MB
EGAF00005329651 fastq.gz 1.3 MB
EGAF00005329652 fastq.gz 28.2 MB
EGAF00005329653 fastq.gz 29.3 MB
EGAF00005329654 fastq.gz 2.0 MB
EGAF00005329655 fastq.gz 2.2 MB
EGAF00005329656 fastq.gz 3.3 MB
EGAF00005329657 fastq.gz 3.6 MB
EGAF00005329658 fastq.gz 211.6 kB
EGAF00005329659 fastq.gz 235.3 kB
EGAF00005329660 fastq.gz 6.8 MB
EGAF00005329661 fastq.gz 7.4 MB
EGAF00005329662 fastq.gz 65.3 MB
EGAF00005329663 fastq.gz 68.1 MB
EGAF00005329664 fastq.gz 175.7 MB
EGAF00005329665 fastq.gz 186.7 MB
EGAF00005329666 fastq.gz 1.5 GB
EGAF00005329667 fastq.gz 1.6 GB
EGAF00005329668 fastq.gz 53.6 MB
EGAF00005329669 fastq.gz 56.0 MB
EGAF00005329670 fastq.gz 31.9 MB
EGAF00005329671 fastq.gz 33.4 MB
EGAF00005329672 fastq.gz 32.4 MB
EGAF00005329673 fastq.gz 33.9 MB
EGAF00005329674 fastq.gz 107.3 MB
EGAF00005329675 fastq.gz 111.8 MB
EGAF00005329676 fastq.gz 70.1 MB
EGAF00005329677 fastq.gz 73.5 MB
EGAF00005329678 fastq.gz 46.5 MB
EGAF00005329679 fastq.gz 48.6 MB
EGAF00005329680 fastq.gz 214.4 kB
EGAF00005329681 fastq.gz 225.0 kB
EGAF00005329682 fastq.gz 84.5 MB
EGAF00005329683 fastq.gz 89.2 MB
EGAF00005329684 fastq.gz 133.5 kB
EGAF00005329685 fastq.gz 137.0 kB
EGAF00005329686 fastq.gz 62.8 MB
EGAF00005329687 fastq.gz 65.3 MB
EGAF00005329688 fastq.gz 204.7 MB
EGAF00005329689 fastq.gz 215.0 MB
EGAF00005329690 fastq.gz 2.8 MB
EGAF00005329691 fastq.gz 3.0 MB
EGAF00005329692 fastq.gz 146.9 MB
EGAF00005329693 fastq.gz 154.7 MB
EGAF00005329694 fastq.gz 3.9 MB
EGAF00005329695 fastq.gz 4.3 MB
EGAF00005329696 fastq.gz 46.0 MB
EGAF00005329697 fastq.gz 47.8 MB
EGAF00005329698 fastq.gz 159.8 MB
EGAF00005329699 fastq.gz 172.9 MB
EGAF00005329700 fastq.gz 2.0 MB
EGAF00005329701 fastq.gz 2.2 MB
EGAF00005329702 fastq.gz 1.3 MB
EGAF00005329703 fastq.gz 1.4 MB
EGAF00005329704 fastq.gz 269.6 MB
EGAF00005329705 fastq.gz 295.2 MB
EGAF00005329706 fastq.gz 174.8 MB
EGAF00005329707 fastq.gz 188.7 MB
EGAF00005329708 fastq.gz 623.5 kB
EGAF00005329709 fastq.gz 674.3 kB
EGAF00005329710 fastq.gz 48.5 MB
EGAF00005329711 fastq.gz 50.4 MB
EGAF00005329712 fastq.gz 135.2 MB
EGAF00005329713 fastq.gz 141.9 MB
EGAF00005329714 fastq.gz 61.1 MB
EGAF00005329715 fastq.gz 64.8 MB
EGAF00005329716 fastq.gz 18.4 MB
EGAF00005329717 fastq.gz 19.2 MB
EGAF00005329718 fastq.gz 94.1 MB
EGAF00005329719 fastq.gz 101.5 MB
EGAF00005329720 fastq.gz 96.3 MB
EGAF00005329721 fastq.gz 99.2 MB
EGAF00005329722 fastq.gz 66.0 MB
EGAF00005329723 fastq.gz 68.7 MB
EGAF00005329724 fastq.gz 31.7 MB
EGAF00005329725 fastq.gz 33.0 MB
EGAF00005329726 fastq.gz 23.4 MB
EGAF00005329727 fastq.gz 23.8 MB
EGAF00005329728 fastq.gz 206.0 kB
EGAF00005329729 fastq.gz 212.4 kB
EGAF00005329730 fastq.gz 12.6 MB
EGAF00005329731 fastq.gz 13.4 MB
EGAF00005329732 fastq.gz 93.9 MB
EGAF00005329733 fastq.gz 99.5 MB
EGAF00005329734 fastq.gz 102.2 MB
EGAF00005329735 fastq.gz 109.0 MB
EGAF00005329736 fastq.gz 43.7 MB
EGAF00005329737 fastq.gz 46.7 MB
EGAF00005329738 fastq.gz 96.1 MB
EGAF00005329739 fastq.gz 100.0 MB
EGAF00005329740 fastq.gz 24.3 MB
EGAF00005329741 fastq.gz 25.3 MB
EGAF00005329742 fastq.gz 45.5 MB
EGAF00005329743 fastq.gz 48.3 MB
EGAF00005329744 fastq.gz 88.2 MB
EGAF00005329745 fastq.gz 92.4 MB
EGAF00005329746 fastq.gz 149.9 MB
EGAF00005329747 fastq.gz 156.2 MB
EGAF00005329748 fastq.gz 141.5 MB
EGAF00005329749 fastq.gz 146.9 MB
EGAF00005329750 fastq.gz 54.4 MB
EGAF00005329751 fastq.gz 56.6 MB
EGAF00005329752 fastq.gz 51.5 MB
EGAF00005329753 fastq.gz 53.7 MB
EGAF00005329754 fastq.gz 72.1 MB
EGAF00005329755 fastq.gz 75.0 MB
EGAF00005329756 fastq.gz 85.8 MB
EGAF00005329757 fastq.gz 90.0 MB
EGAF00005329758 fastq.gz 112.2 MB
EGAF00005329759 fastq.gz 118.3 MB
EGAF00005329760 fastq.gz 32.5 MB
EGAF00005329761 fastq.gz 34.0 MB
EGAF00005329762 fastq.gz 13.3 MB
EGAF00005329763 fastq.gz 13.6 MB
EGAF00005329764 fastq.gz 396.7 kB
EGAF00005329765 fastq.gz 414.1 kB
EGAF00005329766 fastq.gz 1.2 MB
EGAF00005329767 fastq.gz 1.2 MB
EGAF00005329768 fastq.gz 29.4 MB
EGAF00005329769 fastq.gz 30.1 MB
EGAF00005329770 fastq.gz 109.6 MB
EGAF00005329771 fastq.gz 112.2 MB
EGAF00005329772 fastq.gz 20.9 MB
EGAF00005329773 fastq.gz 21.0 MB
EGAF00005329774 fastq.gz 132.2 MB
EGAF00005329775 fastq.gz 137.7 MB
EGAF00005329776 fastq.gz 53.6 MB
EGAF00005329777 fastq.gz 55.3 MB
EGAF00005329778 fastq.gz 39.4 MB
EGAF00005329779 fastq.gz 40.3 MB
EGAF00005329780 fastq.gz 47.0 MB
EGAF00005329781 fastq.gz 50.1 MB
EGAF00005329782 fastq.gz 111.2 MB
EGAF00005329783 fastq.gz 119.0 MB
EGAF00005329784 fastq.gz 73.0 MB
EGAF00005329785 fastq.gz 74.9 MB
EGAF00005329786 fastq.gz 51.0 MB
EGAF00005329787 fastq.gz 53.0 MB
EGAF00005329788 fastq.gz 61.3 MB
EGAF00005329789 fastq.gz 65.1 MB
EGAF00005329790 fastq.gz 1.1 MB
EGAF00005329791 fastq.gz 1.1 MB
EGAF00005329792 fastq.gz 283.5 MB
EGAF00005329793 fastq.gz 301.8 MB
EGAF00005329794 fastq.gz 64.8 MB
EGAF00005329795 fastq.gz 68.7 MB
EGAF00005329796 fastq.gz 63.6 MB
EGAF00005329797 fastq.gz 67.0 MB
EGAF00005329798 fastq.gz 52.8 MB
EGAF00005329799 fastq.gz 55.1 MB
EGAF00005329800 fastq.gz 106.2 MB
EGAF00005329801 fastq.gz 110.9 MB
EGAF00005329802 fastq.gz 49.7 MB
EGAF00005329803 fastq.gz 51.0 MB
EGAF00005329804 fastq.gz 151.0 MB
EGAF00005329805 fastq.gz 156.7 MB
EGAF00005329806 fastq.gz 26.7 MB
EGAF00005329807 fastq.gz 28.4 MB
EGAF00005329808 fastq.gz 92.2 MB
EGAF00005329809 fastq.gz 94.7 MB
EGAF00005329810 fastq.gz 40.2 MB
EGAF00005329811 fastq.gz 41.9 MB
EGAF00005329812 fastq.gz 67.2 MB
EGAF00005329813 fastq.gz 71.0 MB
EGAF00005329814 fastq.gz 820.4 kB
EGAF00005329815 fastq.gz 855.3 kB
172 Files (14.7 GB)