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National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III): Survey (Phenotype) Data Only

This study includes survey (phenotype) data only from the National Epidemiologic Survey on Alcohol and Related Conditions–III (NESARC-III), comprising 36,309 participants and 4,053 phenotypic variables. Individual-level genetic data (N = 22,848 participants), along with corresponding phenotypic variables, are available through a separate dbGaP study (accession: phs001590).

NESARC-III is a nationally representative, cross-sectional survey of the U.S. general population, sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and conducted in 2012–2013. The target population comprised noninstitutionalized U.S. civilians aged 18 and older, including residents of selected group quarters (e.g., group homes and workers' dormitories). Respondents were selected using multistage probability sampling: primary sampling units (PSUs) consisted of individual counties or groups of contiguous counties; secondary sampling units (SSUs) comprised Census-defined block groups; and tertiary sampling units were households within SSUs, from which eligible adults were randomly selected. Hispanics, Blacks, and Asians were oversampled. The final sample included 36,309 respondents, all of whom provided informed consent.

To account for the complex survey design, analyses should incorporate design variables and sampling weights. Users should specify the following in SAS, Stata, or R:

NESARC-III collected detailed information on alcohol and drug use, substance use disorders, psychiatric disorders, physical health conditions, and related risk factors. The dataset also includes extensive sociodemographic variables (e.g., age, sex, race/ethnicity), adverse childhood experiences (e.g., sexual abuse, physical abuse, neglect), family history of substance use and psychiatric disorders, and other environmental risk factors, totaling 4,053 phenotypic variables. Please refer to the supporting documents (e.g., the codebook and questionnaires) for definitions, descriptions of the phenotypic variables, and additional details. The supporting documents can be found in Documents tab in dbGaP or NIAAA website (https://www.niaaa.nih.gov/research/data-archive-resources/niaaa-controlled-datasets/nesarc-iii-study).

DSM-5 diagnostic assessments cover the following conditions:

Substance Use Disorders:

Mood Disorders:

Anxiety Disorders:

Trauma-Related Disorder:

Personality Disorders:

Eating Disorders: