NIMH Alzheimer's Disease Genetics Initiative Family-Based Whole Genome Sequencing Dataset

Samples were obtained at three sites with funding from the National Institute of Mental Health (NIMH). This was a family study known as the National Institute of Mental Health (NIMH) Genetics Initiative. We have been working with these samples since the study's inception and have carried out several GWAS studies on these samples as part of 2R01MH060009-14 “Identification of Functional Genome Variants in Alzheimer's Disease”. Several years ago we performed one of the first sets of whole genome sequencing, which was based on the full NIMH family-based dataset using funding from Cure Alzheimer's Fund. Whole genome sequencing was done at Illumina, Inc. Variants were jointly called for each family using FreeBayes (v0.9.9.2-18) and GATK (v3.0) best practices method as part of the bcbio-nextgen workflow.

This study shares overlapping subjects with phs000483. Subjects with identical dbGaP subject IDs represent the same individuals across both studies. phs000483.v1.p1 provides SNP array data, while the current study provides whole genome sequencing data.

• Type: Pedigree Whole Genome Sequencing
• Archive: The database of Genotypes and Phenotypes (dbGaP)