Kids First: Childhood Cancer Data Initiative (CCDI) - Discovering the Timing and Origins of Bone and Soft Tissue Cancers

Sarcoma are cancers of bone and connective tissue that disproportionately affect children and are often difficult to diagnose. This study presents the genome and transcriptome sequences of carefully curated sarcoma tumors and matched non-neoplastic (normal) specimens including a cohort of benign bone and soft tissue tumors, totalling 1122 sequences from 310 participants, covering 69 various subtypes. High-quality pathology reviewed specimens (FF or FFPE) with detailed clinical data were selected to inform key temporal landmark in sarcoma development – from tumor initiation to the generation of critical oncogenic fusions and malignant potential, to possible relapse or metastasis.

• Type: RNA Sequencing
• Archive: The database of Genotypes and Phenotypes (dbGaP)