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Data has been deposited at the European Genome-phenome Archive (EGA), which is hosted by the EBI and the CRG, under accession number phs001121. Further information about EGA can be found at https://test.ega-archive.org and "The European Genome-phenome Archive of human data consented for biomedical research"

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Integrated Genetic and Pharmacologic Interrogation of Rare Cancers

Due to the paucity of patient derived models in rare cancers, identification of therapeutic targets remains challenging. We developed a patient derived model, CLF-PED-015-T, from a patient with an undifferentiated sarcoma. From this model, we performed pooled RNAi and CRISPR-Cas9 negative selection screens and integrated that with a small molecule screen. Integration of these data identified CDK4 and XPO1 as potential therapeutic targets.

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