Whole-genome sequencing on hepatocellular carcinoma with nodule-in-nodule appearance reveals stepwise cancer evolution

We examined five cases with hypovascular early HCC with hypervascular foci, so-called nodule-in-nodule HCC. Multiregional sampling was performed from both the inner hypervascular region and outer hypovascular region, together with noncancerous liver tissue and lymphocytes as controls. Comprehensive analysis of genomic aberrations, such as single nucleotide variants (SNVs) and structural variations (STVs), was performed by whole-genome sequencing.

• Type: Whole Genome Sequencing
• Archiver: Japanese Genotype-phenotype Archive (JGA)