Study of PD-1 negative CD8 effector T-cells in advanced HCC with single-cell sequencing

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

3 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001011345	scRNAseq and scTCRseq of serial peripheral blood mononuclear cell (PBMC) samples (n=72) taken at various timepoints before and during treatment (Week 0 (W0), Week 3 (W3), Week 6 (W6)). PBMC samples were pooled together into 37 pools, loading 2 or three samples per lane in the 10X Genomics chip, in equal proportions, according to a pre-designed pooling matrix.	Illumina NovaSeq 6000	70
EGAD00001011346	Single cell TotalSeqC protein data serial peripheral blood mononuclear cell (PBMC) samples taken from advanced HCC patients. TotalSeqC is available for 41 out of 72 PBMC samples included in the study, and were combined into 20 pools.	Illumina NovaSeq 6000	20
EGAD00001011347	Single-cell RNA and TCR sequencing of 40 advanced HCC pre-treatment biopsies from 38 patients.	Illumina NovaSeq 6000	80

Publications	Citations
PD-1<sup>-</sup> CD45RA<sup>+</sup> effector-memory CD8 T cells and CXCL10<sup>+</sup> macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma. Cappuyns S, Philips G, Vandecaveye V, Boeckx B, Schepers R, Van Brussel T, Arijs I, Mechels A, Bassez A, Lodi F, Jaekers J, Topal H, Topal B, Bricard O, Qian J, Van Cutsem E, Verslype C, Lambrechts D, Dekervel J. Nat Commun 14: 2023 7825	5
Low-avidity T cells drive endogenous tumor immunity in mice and humans. Singhaviranon S, Dempsey JP, Hagymasi AT, Mandoiu II, Srivastava PK. Nat Immunol 26: 2025 240-251	0

Publications

Citations

PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma.
Cappuyns S, Philips G, Vandecaveye V, Boeckx B, Schepers R, Van Brussel T, Arijs I, Mechels A, Bassez A, Lodi F, Jaekers J, Topal H, Topal B, Bricard O, Qian J, Van Cutsem E, Verslype C, Lambrechts D, Dekervel J. Nat Commun 14: 2023 7825

Low-avidity T cells drive endogenous tumor immunity in mice and humans.
Singhaviranon S, Dempsey JP, Hagymasi AT, Mandoiu II, Srivastava PK. Nat Immunol 26: 2025 240-251