Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens

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Dataset ID	Description	Technology	Samples
EGAD00001011132	In this study we performed whole genome sequencing on matched tumor-normal CD138+ bone marrow mononuclear cells from 60 patients with newly diagnosed multiple myeloma treated with daratumumab, carfilzomib, lenalidomide, and dexamethasone (NCT03290950-MANHATTAN trial). In addition, we performed 5’-single-cell RNA-sequencing (10X Genomics) coupled with V(D)J sequencing and capture of the surface protein markers (TotalSeq-C, Biolegend) of the CD138- bone marrow mononuclear cells to interrogate the composition of the immune microenvironment at baseline and after eight cycles of induction therapy in 22 patients with newly diagnosed multiple myeloma. Samples were multiplexed using hashtag oligo.	Illumina HiSeq 4000 Illumina NovaSeq 6000	131

Publications	Citations
Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens. Maura F, Boyle EM, Coffey D, Maclachlan K, Gagler D, Diamond B, Ghamlouch H, Blaney P, Ziccheddu B, Cirrincione A, Chojnacka M, Wang Y, Siegel A, Hoffman JE, Kazandjian D, Hassoun H, Guzman E, Mailankody S, Shah UA, Tan C, Hultcrantz M, Scordo M, Shah GL, Landau H, Chung DJ, Giralt S, Zhang Y, Arbini A, Gao Q, Roshal M, Dogan A, Lesokhin AM, Davies FE, Usmani SZ, Korde N, Morgan GJ, Landgren O. Nat Cancer 4: 2023 1660-1674	45
Genomic Profiling to Contextualize the Results of Intervention for Smoldering Multiple Myeloma. Kazandjian D, Diamond B, Papadimitriou M, Hill E, Sklavenitis-Pistofidis R, Ziccheddu B, Blaney P, Chojnacka M, Durante M, Maclachlan K, Young R, Usmani S, Davies F, Getz G, Ghobrial I, Korde N, Morgan G, Maura F, Landgren O. Clin Cancer Res 30: 2024 4482-4490	16
The biological and clinical impact of deletions before and after large chromosomal gains in multiple myeloma. Cirrincione AM, Poos AM, Ziccheddu B, Kaddoura M, Bärtsch MA, Maclachlan K, Chojnacka M, Diamond B, John L, Reichert P, Huhn S, Blaney P, Gagler D, Rippe K, Zhang Y, Dogan A, Lesokhin AM, Davies F, Goldschmidt H, Fenk R, Weisel KC, Mai EK, Korde N, Morgan GJ, Usmani S, Landgren O, Raab MS, Weinhold N, Maura F. Blood 144: 2024 771-783	16
Identification of the Distinct Immune Microenvironment Features Associated with Progression Following High-Dose Melphalan and Autologous Stem Cell Transplant in Multiple Myeloma. Sudha P, Johnson TS, Hamidi H, Yang K, Liu E, Smith B, Chopra V, Nixon M, Zafar F, Farag SS, Morgan GJ, Landgren O, Lee K, Suvannasankha A, Czader M, Abonour R, Abu Zaid M, Walker BA. Cancer Immunol Res 13: 2025 1070-1079	1
Temporal genomic dynamics shape clinical trajectory in multiple myeloma. Maura F, Kaddoura M, Poos AM, Baughn LB, Ziccheddu B, Bärtsch MA, Cirrincione A, Maclachlan K, Chojnacka M, Diamond B, Papadimitriou M, Blaney P, John L, Reichert P, Huhn S, Gagler D, Zhang Y, Dogan A, Lesokhin AM, Davies F, Goldschmidt H, Fenk R, Weisel KC, Mai EK, Korde N, Morgan GJ, Rajkumar SV, Kumar S, Usmani S, Landgren O, Raab MS, Weinhold N. Nat Genet 57: 2025 2203-2214	7
Whole-genome sequencing of cell-free DNA for assessment of minimal residual disease in high-risk smoldering multiple myeloma. Baker C, Hill E, Kazandjian D, Papadimitriou M, Durante M, Pandey A, Ziccheddu B, Jelinek T, Coffey D, Walker B, Young R, Maclachlan K, Korde N, Parkinson N, Goldstein ZR, Runnels A, Hooper WF, Landau D, Robine N, Maura F, Landgren O, Diamond B. Hemasphere 10: 2026 e70367	0
Genomic features do not account for differences in multiple myeloma risk by ancestry. Maclachlan KH, Papadimitriou M, Blaney P, Baughn LB, Shekarkhand T, Poos AM, Ziccheddu B, Tang H, Yan H, Diamond B, Zhang Y, Cimera R, Dogan A, Gagler D, Boyle E, Hultcrantz M, Mailankody S, Hassoun H, Shah UA, Tan C, Brown EE, Winterkorn L, Chu T, Steinsnyder Z, Vaksman Z, Davies FE, Korde N, Landgren O, Raab MS, Lesokhin AM, Robine N, Weinhold N, Usmani SZ, Maura F, Morgan GJ. Blood Cancer Discov 7: 2026 742-758	0