bulk TCR-seq data IMCISION

We performed bulk TCR sequencing (Adaptive Biotechnologies, Seattle, WA) on peripheral blood monocytic cells (PBMCs) from 9 HNSCC patients enrolled in the IMCISION trial (Vos et al. 2021) that responded to anti-PD-1 and anti-CTLA4 combination immunotherapy. DNA was extracted from PBMCs that were isolated from pre-treatment and on-treatment blood.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010002546	bulk TCR-seq data IMCISION on the PBMCs of responding patients bulkTCR-seq data generated with the immunoSEQ platform (Adaptive Biotechnologies) on PBMCs of responding patients, pre- and post-treatment.	NextSeq 550	18

Publications	Citations
Dual Immune Checkpoint Blockade Induces Analogous Alterations in the Dysfunctional CD8+ T-cell and Activated Treg Compartment. van der Leun AM, Traets JJH, Vos JL, Elbers JBW, Patiwael S, Qiao X, Machuca-Ostos M, Thommen DS, Haanen JBAG, Schumacher TNM, Zuur CL. Cancer Discov 13: 2023 2212-2227	5