H3Africa - An integrated approach to the identification of genetic determinants of susceptibility to trypanosomiasis

The over-arching aim of this network is to improve the health of people living in some of the poorest countries in the world that carry a disproportionate burden of infectious diseases. Despite their importance, the study of many tropical diseases has lagged behind that of diseases of developed countries. This network will redress the balance by performing high quality research into two neglected tropical diseases, human African Trypanosomiasis (HAT) and schistosomiasis. Our aim is to investigate the genetic determinants of the human reservoirs of HAT and schistosomiasis, filling an important knowledge gap, while extending and strengthening the underpinning infrastructure to deliver these scientific objectives in particular by developing the next generation of African geneticists.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 3 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001011348	TrypanoGEN+ phenotype data containing 183 samples from DRC, Malawi and Uganda.		183
EGAD00001011666	TrypanoGEN+ data containing fastq files of 183 samples from DRC, Malawi and Uganda using NextSeq500.	unspecified	183

Publications	Citations
Transcriptome analysis of peripheral blood of Schistosoma mansoni infected children from the Albert Nile region in Uganda reveals genes implicated in fibrosis pathology. Namulondo J, Nyangiri OA, Kimuda MP, Nambala P, Nassuuna J, Egesa M, Nerima B, Biryomumaisho S, Mugasa CM, Nabukenya I, Kato D, Elliott A, Noyes H, Tweyongyere R, Matovu E, Mulindwa J, TrypanoGEN+ research group of the H3Africa consortium. PLoS Negl Trop Dis 17: 2023 e0011455	0
Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda. Nyangiri OA, Mulindwa J, Namulondo J, Kitibwa A, Nassuuna J, Elliott A, Kimuda MP, Boobo A, Nerima B, Adriko M, Dunton NJ, Madhan GK, Kristiansen M, Casacuberta-Partal M, Noyes H, Matovu E, TrypanoGEN+ Research group of the H3Africa consortium. PLoS Negl Trop Dis 17: 2023 e0011796	0
Transcriptome profiles of Trypanosoma brucei rhodesiense in Malawi reveal focus specific gene expression profiles associated with pathology. Nambala P, Noyes H, Namulondo J, Nyangiri O, Alibu VP, Nerima B, MacLeod A, Matovu E, Musaya J, Mulindwa J, TrypanoGEN+ Research Group as Members of the H3Africa Consortium. PLoS Negl Trop Dis 18: 2024 e0011516	0