Linked-read based analysis of Medulloblastomas
Medulloblastoma (MB) is the most common type of malignant pediatric brain tumor with group 4 medulloblastomas (G4 MBs) accounting for 40% of cases of medulloblastomas. The molecular mechanisms that underlie this subgroup are still poorly understood. Point mutations are detected in a large number of genes at low incidence per gene while the detection of complex structural variants (SVs) in recurrently affected gene typically requires the application of long-read technologies. Here, we applied linked-read sequencing, which combines the long-range genome information of long-read sequencing with the high base pair accuracy of short read sequencing and very low sample input requirements.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001010849 | HiSeq X Ten Illumina NovaSeq 6000 | 50 | |
EGAD00001010850 | unspecified | 12 | |
EGAD00001010851 | MinION PromethION | 5 | |
EGAD00001010852 | unspecified | 10 |
Publications | Citations |
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Linked-read based analysis of the medulloblastoma genome.
Front Oncol 13: 2023 1221611 |
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