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Linked-read based analysis of Medulloblastomas

Medulloblastoma (MB) is the most common type of malignant pediatric brain tumor with group 4 medulloblastomas (G4 MBs) accounting for 40% of cases of medulloblastomas. The molecular mechanisms that underlie this subgroup are still poorly understood. Point mutations are detected in a large number of genes at low incidence per gene while the detection of complex structural variants (SVs) in recurrently affected gene typically requires the application of long-read technologies. Here, we applied linked-read sequencing, which combines the long-range genome information of long-read sequencing with the high base pair accuracy of short read sequencing and very low sample input requirements.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001010849 HiSeq X Ten Illumina NovaSeq 6000 50
EGAD00001010850 unspecified 12
EGAD00001010851 MinION PromethION 5
EGAD00001010852 unspecified 10
Publications Citations
Linked-read based analysis of the medulloblastoma genome.
Front Oncol 13: 2023 1221611
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