Vitamin C boosts DNA demethylation in TET2 germline mutation carriers
We recently identified a family with lymphoma predisposition where a heterozygous truncating germline mutation in TET2 segregated with nodular lymphocyte predominant Hodgkin lymphoma. In a clinical trial of one year, we investigated the effects of oral 1 g/day vitamin C supplementation on DNA methylation by analyzing genome-wide DNA methylation and gene expression patterns from the family members.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001010009 | Illumina NovaSeq 6000 | 24 | |
EGAD00010002410 | Oxford Nanopore | 1 | |
EGAD00010002411 | Oxford Nanopore | 1 | |
EGAD00010002412 | Oxford Nanopore | 1 | |
EGAD00010002413 | Oxford Nanopore | 1 | |
EGAD00010002414 | Oxford Nanopore | 1 | |
EGAD00010002415 | Oxford Nanopore | 1 | |
EGAD00010002416 | Oxford Nanopore | 1 | |
EGAD00010002417 | Oxford Nanopore | 1 | |
EGAD00010002418 | Oxford Nanopore | 24 | |
EGAD00010002419 | Oxford Nanopore | 1 | |
EGAD00010002420 | Oxford Nanopore | 24 | |
EGAD00010002421 | Oxford Nanopore | 1 | |
EGAD00010002422 | Oxford Nanopore | 1 |
Publications | Citations |
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Vitamin C boosts DNA demethylation in TET2 germline mutation carriers.
Clin Epigenetics 15: 2023 7 |
7 |