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Vitamin C boosts DNA demethylation in TET2 germline mutation carriers

We recently identified a family with lymphoma predisposition where a heterozygous truncating germline mutation in TET2 segregated with nodular lymphocyte predominant Hodgkin lymphoma. In a clinical trial of one year, we investigated the effects of oral 1 g/day vitamin C supplementation on DNA methylation by analyzing genome-wide DNA methylation and gene expression patterns from the family members.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001010009 Illumina NovaSeq 6000 24
EGAD00010002410 Oxford Nanopore 1
EGAD00010002411 Oxford Nanopore 1
EGAD00010002412 Oxford Nanopore 1
EGAD00010002413 Oxford Nanopore 1
EGAD00010002414 Oxford Nanopore 1
EGAD00010002415 Oxford Nanopore 1
EGAD00010002416 Oxford Nanopore 1
EGAD00010002417 Oxford Nanopore 1
EGAD00010002418 Oxford Nanopore 24
EGAD00010002419 Oxford Nanopore 1
EGAD00010002420 Oxford Nanopore 24
EGAD00010002421 Oxford Nanopore 1
EGAD00010002422 Oxford Nanopore 1
Publications Citations
Vitamin C boosts DNA demethylation in TET2 germline mutation carriers.
Clin Epigenetics 15: 2023 7
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