Epigenome-wide association study of cocaine use disorder in postmortem human brain tissue

We aimed to identify cocaine use disorder associated DNA methylation alterations in the Brodmann Area 9 brain region.

1 Dataset 2 Publications

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Dataset ID	Description	Technology	Samples
EGAD00010002396	Analysis of cocaine use disorder (CUD) associated epigenome-wide DNA methylation (DNAm) alterations in human postmortem brain tissue of Brodmann Area 9. Tissue samples from N=21 CUD cases and N=21 individuals without CUD originating from the Douglas Bell Canada Brain Bank (DBCBB) were included. Epigenome-wide DNAm was investigated using the Illumina Infinium MethylationEPIC array.	Infinium MethylationEPIC array	84

Publications	Citations
DNA methylation in cocaine use disorder-An epigenome-wide approach in the human prefrontal cortex. Poisel E, Zillich L, Streit F, Frank J, Friske MM, Foo JC, Mechawar N, Turecki G, Hansson AC, Nöthen MM, Rietschel M, Spanagel R, Witt SH. Front Psychiatry 14: 2023 1075250	12
Multi-omics profiling of DNA methylation and gene expression alterations in human cocaine use disorder. Zillich E, Belschner H, Avetyan D, Andrade-Brito D, Martínez-Magaña JJ, Frank J, Mechawar N, Turecki G, Cabana-Domínguez J, Fernàndez-Castillo N, Cormand B, Montalvo-Ortiz JL, Nöthen MM, Hansson AC, Rietschel M, Spanagel R, Witt SH, Zillich L. Transl Psychiatry 14: 2024 428	0