scRNAseq and scATACseq of placebo controlled-trial on MMR non-specific effects

The project includes sequencing data of isolated PBMCs extracted from donors that received the MMR vaccine and donors that received placebo, both containg samples before and after the vaccine. In total, 6 MMR-vaccinated and 6 Placebo donors for both timepoints were included in the scRNAseq data. In total, 12 MMR-vaccinated and 12 Placebo donors for both timepoints were included in the scATACseq data. The main goal of the project is studying the non-specific effects of the vaccine and its possible use as an inducer of trained immunity in vivo.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001010012	Dataset containing 48 samples: 12 per timepoint (before or after treatment) and group (MMR vaccine or Placebo). Each sequencing run contains the sequencing data from 4 randomized samples. Genotype data is used to demultiplex sample ids inside of each pool. Phenotype data contains the information per pool.	Illumina NovaSeq 6000	23

Publications	Citations
MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells. Röring RJ, Debisarun PA, Botey-Bataller J, Suen TK, Bulut Ö, Kilic G, Koeken VA, Sarlea A, Bahrar H, Dijkstra H, Lemmers H, Gössling KL, Rüchel N, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ariyurek Y, de Meijer EJ, Kloet SL, Ten Oever J, Placek K, Li Y, Netea MG. J Clin Invest 134: 2024 e170848	5

Publications

Citations

MMR vaccination induces trained immunity via functional and metabolic reprogramming of γδ T cells.
Röring RJ, Debisarun PA, Botey-Bataller J, Suen TK, Bulut Ö, Kilic G, Koeken VA, Sarlea A, Bahrar H, Dijkstra H, Lemmers H, Gössling KL, Rüchel N, Ostermann PN, Müller L, Schaal H, Adams O, Borkhardt A, Ariyurek Y, de Meijer EJ, Kloet SL, Ten Oever J, Placek K, Li Y, Netea MG. J Clin Invest 134: 2024 e170848