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Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma

SOX11 is overexpressed in the highly aggressive conventional mantle cell lymphoma (MCL) but rarely in the indolent non-nodal MCL subtype. We performed RNA-seq of SOX11+ and SOX11- MCLs to search for SOX11-regulated genes that contributed to MCL clinical evolution, identifying Musashi-2 (MSI2) stem cell-related gene. By performing RNA-seq upon MSI2 knockdown or inhibition in MCL, we identified MSI2 as a potential target to inhibit drug resistance in aggressive MCLs.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001009420 Illumina HiSeq 2500 14
EGAD00001009421 Illumina HiSeq 2500 12
EGAD00001009422 Illumina HiSeq 2500 12
Publications Citations
Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
Leukemia 37: 2023 408-421
2
SOX11/PRDX2 axis modulates redox homeostasis and chemoresistance in aggressive mantle cell lymphoma.
Sci Rep 14: 2024 7863
0