Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma
SOX11 is overexpressed in the highly aggressive conventional mantle cell lymphoma (MCL) but rarely in the indolent non-nodal MCL subtype. We performed RNA-seq of SOX11+ and SOX11- MCLs to search for SOX11-regulated genes that contributed to MCL clinical evolution, identifying Musashi-2 (MSI2) stem cell-related gene. By performing RNA-seq upon MSI2 knockdown or inhibition in MCL, we identified MSI2 as a potential target to inhibit drug resistance in aggressive MCLs.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001009420 | Illumina HiSeq 2500 | 14 | |
EGAD00001009421 | Illumina HiSeq 2500 | 12 | |
EGAD00001009422 | Illumina HiSeq 2500 | 12 |
Publications | Citations |
---|---|
Tumorigenic role of Musashi-2 in aggressive mantle cell lymphoma.
Leukemia 37: 2023 408-421 |
2 |
SOX11/PRDX2 axis modulates redox homeostasis and chemoresistance in aggressive mantle cell lymphoma.
Sci Rep 14: 2024 7863 |
0 |