Ovarian carcinosarcoma genomics and eribulin response

Ovarian carcinosarcoma (OCS) is an aggressive and rare tumour type with limited treatment options. OCS is hypothesised to develop via the combination theory, with a single progenitor resulting in carcinomatous and sarcomatous components, or alternatively via the conversion theory, with the sarcomatous component developing from the carcinomatous component through epithelial-to-mesenchymal transition (EMT). In this study, we analysed DNA variants from isolated carcinoma and sarcoma components to show that OCS from 18 women is monoclonal. RNA sequencing indicated the carcinoma components were more mesenchymal when compared with pure epithelial ovarian carcinomas, supporting the conversion theory and suggesting that EMT is important in the formation of these tumours.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

4 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001009657	2 patient-derived xenograph tumours, and associated normal blood samples. Duplicated samples for each gave 8 pairs of fastq files	Illumina NovaSeq 6000	8
EGAD00001009658	RNAseq from PDX tumours under treatment with dpbs or eribulin. Sarcomatous or mixed sarcoma/carcinoma. 6 PDX tumours each with 2 treatments gave 12 pairs of fastq files.	Illumina NovaSeq 6000	12
EGAD00001009659	Original patient tumours from which PDX models were derived. TruSight Oncology RNA panel for 2 samples, sequenced over 4 lanes each, gave 8 pairs of fastq files	Illumina HiSeq 4000	8
EGAD00001009660	5 samples as fastq file pairs. 1 solid tumour sample from patient #1105 with matched blood, and 2 solid tumour samples from patient #1177 with matched blood.	Illumina NovaSeq 6000	5

Publications	Citations
Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin. Ho GY, Kyran EL, Bedo J, Wakefield MJ, Ennis DP, Mirza HB, Vandenberg CJ, Lieschke E, Farrell A, Hadla A, Lim R, Dall G, Vince JE, Chua NK, Kondrashova O, Upstill-Goddard R, Bailey UM, Dowson S, Roxburgh P, Glasspool RM, Bryson G, Biankin AV, Scottish Genomes Partnership, Cooke SL, Ratnayake G, McNally O, Traficante N, Australian Ovarian Cancer Study12,13, DeFazio A, Weroha SJ, Bowtell DD, McNeish IA, Papenfuss AT, Scott CL, Barker HE. Cancer Res 82: 2022 4457-4473	9

Publications

Citations

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.
Ho GY, Kyran EL, Bedo J, Wakefield MJ, Ennis DP, Mirza HB, Vandenberg CJ, Lieschke E, Farrell A, Hadla A, Lim R, Dall G, Vince JE, Chua NK, Kondrashova O, Upstill-Goddard R, Bailey UM, Dowson S, Roxburgh P, Glasspool RM, Bryson G, Biankin AV, Scottish Genomes Partnership, Cooke SL, Ratnayake G, McNally O, Traficante N, Australian Ovarian Cancer Study12,13, DeFazio A, Weroha SJ, Bowtell DD, McNeish IA, Papenfuss AT, Scott CL, Barker HE. Cancer Res 82: 2022 4457-4473