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in silico drug target prediction for melanoma

The in silico single gene deletion step was adapted to simulate the knock-out of all targets of a drug on an objective function such as growth or energy balance. Based on publicly available and in-house large scale transcriptomic data, metabolic models for melanoma were reconstructed, enabling the prediction of 28 candidate drugs and estimating their respective efficacy.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001009089 NextSeq 500 31
Publications Citations
Metabolic modelling-based in silico drug target prediction identifies six novel repurposable drugs for melanoma.
Cell Death Dis 14: 2023 468
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