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Somatic L1 retrotranspositions in normal human cells

Genomic mutations accumulate in normal cells during lifetime; however, somatic mosaicism generated by mobilization of transposable elements is not well understood. Here, we explored whole-genome sequences of single-cell expanded clones to illustrate the mutational landscape produced by L1. In addition, we analyzed promoter DNA methylation status of retrotransposition-competent L1 and read-through RNA expression profiles to investigate the epigenetic regulation of L1 activity.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001010183 Illumina NovaSeq 6000 654
Publications Citations
Widespread somatic L1 retrotransposition in normal colorectal epithelium.
Nature 617: 2023 540-547
12
Mitochondrial DNA mosaicism in normal human somatic cells.
Nat Genet 56: 2024 1665-1677
1