Somatic L1 retrotranspositions in normal human cells
Genomic mutations accumulate in normal cells during lifetime; however, somatic mosaicism generated by mobilization of transposable elements is not well understood. Here, we explored whole-genome sequences of single-cell expanded clones to illustrate the mutational landscape produced by L1. In addition, we analyzed promoter DNA methylation status of retrotransposition-competent L1 and read-through RNA expression profiles to investigate the epigenetic regulation of L1 activity.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001010183 | Illumina NovaSeq 6000 | 654 |
Publications | Citations |
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Widespread somatic L1 retrotransposition in normal colorectal epithelium.
Nature 617: 2023 540-547 |
12 |
Mitochondrial DNA mosaicism in normal human somatic cells.
Nat Genet 56: 2024 1665-1677 |
1 |