Spatial atlas of clonal copy number alterations in co-existing benign and malignant tissue
Defining the transition from benign to malignant tissue is fundamental to improve early diagnosis of cancer. Here, we use a systematic approach to study spatial genome integrity in situ and describe previously unidentified clonal relationships. We employed spatially resolved transcriptomics to infer spatial copy number variations in >120,000 regions across multiple organs, in benign and malignant tissues. We demonstrate that genome-wide copy number variation reveals distinct clonal patterns within tumours and in nearby benign tissue using an organ-wide approach focused on the prostate. Our results suggest a model for how genomic instability arises in histologically benign tissue that may represent early events in cancer evolution. We highlight the power of capturing the molecular and spatial continuums in a tissue context and challenge the rationale for treatment paradigms, including focal therapy.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
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EGAD00001008644 | Illumina NovaSeq 6000 unspecified | 58 |
Publications | Citations |
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Spatially resolved clonal copy number alterations in benign and malignant tissue.
Nature 608: 2022 360-367 |
82 |
Spatial transcriptomic analysis of virtual prostate biopsy reveals confounding effect of tissue heterogeneity on genomic signatures.
Mol Cancer 22: 2023 162 |
2 |
Metabolic imaging across scales reveals distinct prostate cancer phenotypes.
Nat Commun 15: 2024 5980 |
0 |
<i>DAB2</i> <sup>+</sup> macrophages support <i>FAP</i> <sup>+</sup> fibroblasts in shaping tumor barrier and inducing poor clinical outcomes in liver cancer.
Theranostics 14: 2024 4822-4843 |
0 |
Inferring allele-specific copy number aberrations and tumor phylogeography from spatially resolved transcriptomics.
Nat Methods 21: 2024 2239-2247 |
2 |