Profiling of 27 type 2 diabetes GWAS loci using next-generation (NG) capture C in a human beta-cell model

Most type 2 diabetes association signals are due to variants that impact gene regulation but identifying the genes they impact is challenging. We generated interaction profiles at 27 T2D GWAS loci using next-generation (NG) capture C in a human beta-cell model ( EndoC-betaH1) and contrasted our maps with public Hi-C/promoter capture Hi-C maps in EndoC-betaH1 cells or human islets.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Publication

Publications	Citations
Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells. Torres JM, Sun H, Nylander V, Downes DJ, van de Bunt M, McCarthy MI, Hughes JR, Gloyn AL. Wellcome Open Res 8: 2023 165	0