Molecular programs of melanoma brain metastases (MBM)

We performed paired-end whole transcriptome sequencing of fresh frozen or intraoperative brain metastases of therapeutically treated stage IV melanoma patients. In addition, we analysed the epigenetic landscape of tumors usind Illumina 850k bead chip technology.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001008508	Whole transcriptome and 850k mehylome profiling of human intraoperative or snap frozen and FFPE MBM.	Illumina NovaSeq 6000	21

Publications	Citations
Decoding molecular programs in melanoma brain metastases. Radke J, Schumann E, Onken J, Koll R, Acker G, Bodnar B, Senger C, Tierling S, Möbs M, Vajkoczy P, Vidal A, Högler S, Kodajova P, Westphal D, Meier F, Heppner F, Kreuzer-Redmer S, Grebien F, Jürchott K, Redmer T. Nat Commun 13: 2022 7304	6
MET receptor serves as a promising target in melanoma brain metastases. Redmer T, Schumann E, Peters K, Weidemeier ME, Nowak S, Schroeder HWS, Vidal A, Radbruch H, Lehmann A, Kreuzer-Redmer S, Jürchott K, Radke J. Acta Neuropathol 147: 2024 44	1