Failure of Differentiation of the Rhombic Lip Constitutes Medulloblastoma
We used single-cell transcriptomics to study cells from the developing human cerebellum, and show that different molecular subgroups of medulloblastoma resemble distinct glutamatergic progenitors.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001008381 | Illumina NovaSeq 6000 | 13 | |
EGAD00001008458 | Illumina HiSeq 2000 Illumina HiSeq 2500 | 391 |
Publications | Citations |
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Failure of human rhombic lip differentiation underlies medulloblastoma formation.
Nature 609: 2022 1021-1028 |
50 |
The LIN28B-let-7-PBK pathway is essential for group 3 medulloblastoma tumor growth and survival.
Mol Oncol 17: 2023 1784-1802 |
4 |
Heterogeneity and tumoral origin of medulloblastoma in the single-cell era.
Oncogene 43: 2024 839-850 |
1 |
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing.
Nat Cell Biol 26: 2024 1233-1246 |
0 |