Sequencing data for CLL patients

Single-cell RNA-sequencing and other genome-wide approaches were applied to a cohort of CLL patients receiving Venetoclax treatment to study mechanisms of resistance.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

5 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001008365	Captured single-cell long-read data of a cohort of CLL patients receiving VEN treatment for resistance study	PromethION	25
EGAD00001008366	CITEseq data of CLL patients receiving VEN treatment for resistance study	NextSeq 500	25
EGAD00001008367	Single-cell Long read data of a cohort of CLL patients receiving Venetoclax treatment for VEN resistance study.	PromethION	25
EGAD00001008664	Whole exon sequencing data of CLL patients	NextSeq 500	27
EGAD00001008665	ChIPseq data for CLL patients	NextSeq 500	3

Publications	Citations
Single-cell multiomics reveal the scale of multilayered adaptations enabling CLL relapse during venetoclax therapy. Thijssen R, Tian L, Anderson MA, Flensburg C, Jarratt A, Garnham AL, Jabbari JS, Peng H, Lew TE, Teh CE, Gouil Q, Georgiou A, Tan T, Djajawi TM, Tam CS, Seymour JF, Blombery P, Gray DHD, Majewski IJ, Ritchie ME, Roberts AW, Huang DCS. Blood 140: 2022 2127-2141	32