Pediatric HGG WES and RNA-Seq

Paediatric high-grade glioma (pHGG) is the leading cause of paediatric brain tumour death. Here we performed RNA and whole exome sequencing on pHGG samples to analyse transcriptomic and genetic alterations associated with this devastating disease, and to understand the relationship between them.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001008278	We performed RNA-Seq in DIPG and hemispheric HGG.	Illumina HiSeq 2500	40
EGAD00001008279	We performed whole exome sequencing in DIPG and hemispheric HGG.	Illumina HiSeq 2500 Ion Torrent Proton	30

Publications	Citations
Splicing is an alternate oncogenic pathway activation mechanism in glioma. Siddaway R, Milos S, Vadivel AKA, Dobson THW, Swaminathan J, Ryall S, Pajovic S, Patel PG, Nazarian J, Becher O, Brudno M, Ramani A, Gopalakrishnan V, Hawkins C. Nat Commun 13: 2022 588	20
Immuno-oncologic profiling of pediatric brain tumors reveals major clinical significance of the tumor immune microenvironment. Levine AB, Nobre L, Das A, Milos S, Bianchi V, Johnson M, Fernandez NR, Stengs L, Ryall S, Ku M, Rana M, Laxer B, Sheth J, Sbergio SG, Fedoráková I, Ramaswamy V, Bennett J, Siddaway R, Tabori U, Hawkins C. Nat Commun 15: 2024 5790	1