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MM samples for epigenomic translocation of H3K4me3 broad domains following super-enhancer hijacking

Chromosomal translocations are important drivers of haematological malignancies whereby proto-oncogenes are activated by juxtaposition with super-enhancers, often called enhancer hijacking. To examine this phenomenon we used ChipSeq based on a combination of six histone modifications as follows: H3K4me1, H3K4me3, H3K9me3, H3K27me3, H3K27Ac and H3K36me3. Samples are patient-derived xenografts generated by passaging primary patient CD138+ selected cells through the SCID-rab myeloma mouse model.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001008353 unspecified 42
Publications Citations
Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers.
Genome Res 32: 2022 1343-1354
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