ADAPTeR Study: scRNA and scTCR data from TILs from two ccRCC patients treated with anti-PD1

TILs were extracted from two ccRCC patients treated with (Nivolumab) anti-PD1, one was responsive to treatment, the other non-responsive. IgG4 staining was used to separate cells into anti-PD1 bound and unbound, the samples then underwent paired scRNA and scTCR sequencing on the 10x Genomics platform.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001008166	ADAPTeR study scRNA and scTCR data from TILs from two ccRCC patients treated with nivolumab	NextSeq 550	64

Publications	Citations
Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma. Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M, PEACE Consortium, Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S, TRACERx Renal Consortium. Cancer Cell 39: 2021 1497-1518.e11	107
Single-Cell Analysis Identifies Distinct Populations of Cytotoxic CD4<sup>+</sup> T Cells Linked to the Therapeutic Efficacy of Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma. Yang X, Wu J, Fan L, Chen B, Zhang S, Zheng W. J Inflamm Res 17: 2024 4505-4523	0

Publications

Citations

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma.
Au L, Hatipoglu E, Robert de Massy M, Litchfield K, Beattie G, Rowan A, Schnidrig D, Thompson R, Byrne F, Horswell S, Fotiadis N, Hazell S, Nicol D, Shepherd STC, Fendler A, Mason R, Del Rosario L, Edmonds K, Lingard K, Sarker S, Mangwende M, Carlyle E, Attig J, Joshi K, Uddin I, Becker PD, Sunderland MW, Akarca A, Puccio I, Yang WW, Lund T, Dhillon K, Vasquez MD, Ghorani E, Xu H, Spencer C, López JI, Green A, Mahadeva U, Borg E, Mitchison M, Moore DA, Proctor I, Falzon M, Pickering L, Furness AJS, Reading JL, Salgado R, Marafioti T, Jamal-Hanjani M, PEACE Consortium, Kassiotis G, Chain B, Larkin J, Swanton C, Quezada SA, Turajlic S, TRACERx Renal Consortium. Cancer Cell 39: 2021 1497-1518.e11

107

Single-Cell Analysis Identifies Distinct Populations of Cytotoxic CD4<sup>+</sup> T Cells Linked to the Therapeutic Efficacy of Immune Checkpoint Inhibitors in Metastatic Renal Cell Carcinoma.
Yang X, Wu J, Fan L, Chen B, Zhang S, Zheng W. J Inflamm Res 17: 2024 4505-4523