Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma

TP53 alterations are associated with adverse outcome in many malignancies; however, whilst common in paediatric B-NHL, their utility as a risk classifier in this setting is unknown. We evaluated the clinical significance of TP53 abnormalities (mutations, deletion and/or copy number neutral loss of heterozygosity) in a large UK paediatric B-NHL cohort (n=95) and determined their impact on survival.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets

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Dataset ID	Description	Technology	Samples
EGAD00001008162	Whole exome sequencing data from 90 diagnostic lymphoma samples run and published as part of the Leukemia manuscript. 133 total exomes were sequenced including tumour and normal controls. Copy number array data was also generated for 95 patients.	Illumina HiSeq 2500	91
EGAD00010002235	CN Array samples from lymphoma patient tumours on Affymetrix platforms	Affymetrix Oncoscan, Affymetrix SNP6.0, Affymetrix Cytocan HD	95