Application of Hi-C sequencing to detect structural variants in B-cell acute lymphoblastic leukemia

Large structural variants are easily detected by Hi-C sequencing as strong, distant signals on a Hi-C contact map. Translocations are frequently evident in B-ALL and accurate identification of these translocations can guide clinical treatment options. Here were apply shallow Hi-C sequencing as an unbiased, cost-effective approach to identify translocations among B-ALL patients.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001008125	Hi-C sequencing data includes 5 samples collected from 4 B-ALL patients.	NextSeq 500	5

Publications	Citations
Hi-C detects genomic structural variants in peripheral blood of pediatric leukemia patients. Mallard C, Johnston MJ, Bobyn A, Nikolic A, Argiropoulos B, Chan JA, Guilcher GMT, Gallo M. Cold Spring Harb Mol Case Stud 8: 2022 a006157	9