Pancreatic islets PISA RNA-seq samples
GWAS have identified more than 700 genetic signals associated with type 2 diabetes (T2D). To gain insight into the underlying molecular mechanisms, we created the Translational human pancreatic Islet Genotype tissue-Expression Resource (TIGER), aggregating >500 human islet RNA-seq and genotyping datasets. We imputed genotypes using 4 reference panels and meta-analyzed cohorts to improve coverage of expression quantitative trait loci (eQTL) and developed a method to combine allele-specific expression across samples (cASE). We identified >1 million islet eQTLs (56% novel), of which 53 colocalize with T2D signals (60% novel). Among them, a low-frequency allele that reduces T2D risk by half increases CCND2 expression. We identified 8 novel cASE colocalizations, among which an SLC30A8 T2D associated variant. We make all the data available through the open-access TIGER portal (http://tiger.bsc.es), which represents a comprehensive human islet genomic data resource to elucidate how genetic variation affects islet function and translate this into therapeutic insight and precision medicine for T2D.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001007990 | unspecified | 127 | |
EGAD00010002218 | Illumina | 127 |
Publications | Citations |
---|---|
TIGER: The gene expression regulatory variation landscape of human pancreatic islets.
Cell Rep 37: 2021 109807 |
42 |
Genetic regulation of RNA splicing in human pancreatic islets.
Genome Biol 23: 2022 196 |
15 |
Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies.
iScience 25: 2022 105376 |
3 |
Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function.
Nat Commun 15: 2024 6627 |
0 |