Paired exome and low-coverage genome sequencing of osteosarcoma

We perform longitudinal genome-sequencing analysis of 12 patients with metastatic or refractory osteosarcoma. The study was approved at the University Hospital Basel, following the approval of the ethical committee for mutational analysis of anonymized samples (“Ethikkommission beider Basel” ref. 274/12). All tumor samples were evaluated by an experienced bone pathologist to conﬁrm the diagnosis.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD00001007509	Longitudinal genome-sequencing analysis of 12 patients with metastatic or refractory osteosarcoma. The study was approved at the University Hospital Basel, following the approval of the ethical committee for mutational analysis of anonymized samples (“Ethikkommission beider Basel” ref. 274/12). Informed consent was obtained from all 12 patients. All tumor samples were evaluated by an experienced bone pathologist to conﬁrm the diagnosis. WES and low coverage WGS are aligned against the reference genome GRCh37. More details in the associated publication.	Illumina HiSeq 4000	72

Publications	Citations
The early evolutionary landscape of osteosarcoma provides clues for targeted treatment strategies. Kovac M, Ameline B, Ribi S, Kovacova M, Cross W, Barenboim M, Witt O, Bielack S, Krieg A, Hartmann W, Nathrath M, Baumhoer D. J Pathol 254: 2021 556-566	7