Platelet response in aspirin adherent pregnant women

We conducted an unbiased genome-wide assessment of genomic factors that may influence response to low-dose aspirin in pregnant women at high risk of pre-eclampsia in two pregnancy cohorts: Liverpool (n=91) and Dublin (n=91). We applied UK Axiom microarray technology for GWAS investigations. We specified tight phenotyping with COX-selective urinary 11-dehydrothromboxane B2 (pg/mg creatinine) and accounted for adherence/platelet exposure to aspirin by detection of aspirin’s principal urinary metabolite, SUA, with nuclear magnetic resonance (NMR).

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets

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Dataset ID	Description	Technology	Samples
EGAD00010002093	Dublin Aspirin platelet response genomics cohort	UK Biobank Axiom array	91
EGAD00010002094	Liverpool Aspirin platelet response genomics cohort	UK Biobank Axiom array	91