Single-cell multi-omic profiling of glioblastoma-associated myeloid cells

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006778	Single cell RNA and CITE sequencing of newly-diagnosed and recurrent GBM	Illumina HiSeq 4000 Illumina NovaSeq 6000	15

Publications	Citations
Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha. De Vlaminck K, Romão E, Puttemans J, Pombo Antunes AR, Kancheva D, Scheyltjens I, Van Ginderachter JA, Muyldermans S, Devoogdt N, Movahedi K, Raes G. Front Immunol 12: 2021 777524	23
Targeting the TREM1-positive myeloid microenvironment in glioblastoma. Filippova N, Grimes JM, Leavenworth JW, Namkoong D, Yang X, King PH, Crowley M, Crossman DK, Nabors LB. Neurooncol Adv 4: 2022 vdac149	6
GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide. Parik S, Fernández-García J, Lodi F, De Vlaminck K, Derweduwe M, De Vleeschouwer S, Sciot R, Geens W, Weng L, Bosisio FM, Bergers G, Duerinck J, De Smet F, Lambrechts D, Van Ginderachter JA, Fendt SM. Front Oncol 12: 2022 988872	34
Global hypo-methylation in a proportion of glioblastoma enriched for an astrocytic signature is associated with increased invasion and altered immune landscape. Boot J, Rosser G, Kancheva D, Vinel C, Lim YM, Pomella N, Zhang X, Guglielmi L, Sheer D, Barnes M, Brandner S, Nelander S, Movahedi K, Marino S. Elife 11: 2022 e77335	9
The diversity and dynamics of tumor-associated macrophages in recurrent glioblastoma. Zhang L, Jiang Y, Zhang G, Wei S. Front Immunol 14: 2023 1238233	23
Pilot Screening of TREM1 Inhibitors in Cell-Based Reporter Assays Reflecting TREM1/DAP12 Receptor Assembly and Functionality. Filippova N, Hromov R, Shi J, King PH, Nabors LB. ACS Chem Neurosci 16: 2025 52-65	1
Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression. Liu Y, Pang L, Khan F, Wu J, Zhou F, Horbinski C, Bao S, Yu JS, Lathia JD, Chen P. JCI Insight 10: 2025 e187684	3