Cell types of the human retina and its organoids at single-cell resolution. Cowan et al

Human organoids recapitulating the cell-type diversity and function of their target organ are valuable for basic and translational research. We developed light-sensitive human retinal organoids with multiple nuclear and synaptic layers, and functional synapses. We sequenced the RNA of 285,441 single cells from these organoids at seven developmental time points and from the periphery, fovea, pigment epithelium and choroid of light-responsive adult human retinas.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 2 Publications

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Dataset ID	Description	Technology	Samples
EGAD00001006350	Human organoids recapitulating the cell-type diversity and function of their target organ are valuable for basic and translational research. We developed light-sensitive human retinal organoids with multiple nuclear and synaptic layers, and functional synapses. We sequenced the RNA of 285,441 single cells from these organoids at seven developmental time points and from the periphery, fovea, pigment epithelium and choroid of light-responsive adult human retinas.	Illumina HiSeq 2500	124

Publications	Citations
Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution. Cowan CS, Renner M, De Gennaro M, Gross-Scherf B, Goldblum D, Hou Y, Munz M, Rodrigues TM, Krol J, Szikra T, Cuttat R, Waldt A, Papasaikas P, Diggelmann R, Patino-Alvarez CP, Galliker P, Spirig SE, Pavlinic D, Gerber-Hollbach N, Schuierer S, Srdanovic A, Balogh M, Panero R, Kusnyerik A, Szabo A, Stadler MB, Orgül S, Picelli S, Hasler PW, Hierlemann A, Scholl HPN, Roma G, Nigsch F, Roska B. Cell 182: 2020 1623-1640.e34	251
Comprehensive Characterization of a Subfamily of Ca<sup>2+</sup>-Binding Proteins in Mouse and Human Retinal Neurons at Single-Cell Resolution. Liu JB, Yuan HL, Zhang G, Ke JB. eNeuro 11: 2024 ENEURO.0145-24.2024	0

Publications

Citations

Cell Types of the Human Retina and Its Organoids at Single-Cell Resolution.
Cowan CS, Renner M, De Gennaro M, Gross-Scherf B, Goldblum D, Hou Y, Munz M, Rodrigues TM, Krol J, Szikra T, Cuttat R, Waldt A, Papasaikas P, Diggelmann R, Patino-Alvarez CP, Galliker P, Spirig SE, Pavlinic D, Gerber-Hollbach N, Schuierer S, Srdanovic A, Balogh M, Panero R, Kusnyerik A, Szabo A, Stadler MB, Orgül S, Picelli S, Hasler PW, Hierlemann A, Scholl HPN, Roma G, Nigsch F, Roska B. Cell 182: 2020 1623-1640.e34

251

Comprehensive Characterization of a Subfamily of Ca<sup>2+</sup>-Binding Proteins in Mouse and Human Retinal Neurons at Single-Cell Resolution.
Liu JB, Yuan HL, Zhang G, Ke JB. eNeuro 11: 2024 ENEURO.0145-24.2024