An epigenetic single-cell atlas of IDH-mutant glioma reveals the role of ATRX in shaping tumor composition

Recent single-cell RNA-sequencing studies have identified a hierarchy of cell types that is common to all isocitrate dehydrogenase (IDH) -mutant gliomas. This finding is somewhat paradoxical since the genetic differences between IDH-mutant astrocytomas and IDH-mutant oligodendrogliomas are prognostic, predictive of therapeutic response, and correlated with differences in immune infiltrates. To integrate these disparate findings, we constructed a single-cell atlas of 22 human IDH-mutant primary untreated grade-II/III gliomas.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

21 Datasets 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001006311	SF11940 snATAC Sequencing.Anaplastic Astrocytoma, IDH-mutant. Tumor location: Left Frontal. Age: 29. Sex: Male .	Illumina NovaSeq 6000	1
EGAD00001006312	SF10679 snATAC Seq. Oligodendroglioma, Anaplastic (WHO gr. 3). Tumor Location: Frontal Age: 43. Sex: Male.	Illumina NovaSeq 6000	1
EGAD00001006313	SF11310 Oligodendroglioma, IDH-mutant.Tumor Location: Frontal. Age:22. Sex: Female	Illumina NovaSeq 6000	1
EGAD00001006314	SF10320 Unknown.	Illumina NovaSeq 6000	1
EGAD00001006315	SF12374 snATAC Oligodendroglioma. Tumor Location: Right frontal. Age: 33. Sex: Male.	Illumina NovaSeq 6000	1
EGAD00001006316	SF10619 snATAC Oligodendroglioma (WHO gr. 2).Tumor Location: Parietal. Age: 52. Sex: Male	Illumina NovaSeq 6000	1
EGAD00001006317	SF4007 snATAC Seq. Oligodendroglioma (WHO gr. 2) Tumor Location: Left frontotemporal. Age:33. Sex: Female.	Illumina NovaSeq 6000	1
EGAD00001006318	Astrocytoma (WHO gr. 2)	Illumina NovaSeq 6000	2
EGAD00001006319	SF10207 snATAC Seq. Oligodendroglioma, Anaplastic (WHO gr. 3). Tumor Location:Frontal. Age:43. Sex: Male	Illumina NovaSeq 6000	1
EGAD00001008297	Oligodendroglioma (WHO gr. 2)	Illumina NovaSeq 6000	1
EGAD00001008298	Oligodendroglioma, Anaplastic (WHO gr. 3	Illumina NovaSeq 6000	1
EGAD00001008299	Oligodendroglioma (WHO gr. 2	Illumina NovaSeq 6000	1
EGAD00001008300	Oligodendroglioma (WHO gr. 2	Illumina NovaSeq 6000	1
EGAD00001008301	Oligodendroglioma, IDH-mutant, 1p19q codeleted	Illumina NovaSeq 6000	1
EGAD00001008302	Oligodendroglioma, Anaplastic (WHO gr. 3	Illumina NovaSeq 6000	1
EGAD00001008303	Unknown	Illumina NovaSeq 6000	1
EGAD00001008304	Anaplastic Astrocytoma, IDH-mutant	Illumina NovaSeq 6000	1
EGAD00001008305	Astrocytoma (WHO gr. 2)	Illumina NovaSeq 6000	1
EGAD00001008306	Oligodendroglioma (WHO gr. 2)	Illumina NovaSeq 6000	1
EGAD00001008307	Astrocytoma, Anaplastic (WHO gr. 3	Illumina NovaSeq 6000	1
EGAD00001008308	Oligodendroglioma (WHO gr. 2)	Illumina NovaSeq 6000	1

Publications	Citations
ATRX regulates glial identity and the tumor microenvironment in IDH-mutant glioma. Babikir H, Wang L, Shamardani K, Catalan F, Sudhir S, Aghi MK, Raleigh DR, Phillips JJ, Diaz AA. Genome Biol 22: 2021 311	26
Stalled oligodendrocyte differentiation in IDH-mutant gliomas. Wei Y, Li G, Feng J, Wu F, Zhao Z, Bao Z, Zhang W, Su X, Li J, Qi X, Duan Z, Zhang Y, Vega SF, Jakola AS, Sun Y, Carén H, Jiang T, Fan X. Genome Med 15: 2023 24	8