ImmunoAgeing_Colonies_WGS

Aim to determine age at acquisition of clonal haematopoiesis mutations, clonal architecture, and dynamics of clonal expansions.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 4 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001007684	Whole-genome sequencing of 288 single-cell-derived blood colonies from 3 elderly individuals with clonal haematopoiesis.	Illumina NovaSeq 6000	1

Publications	Citations
The longitudinal dynamics and natural history of clonal haematopoiesis. Fabre MA, de Almeida JG, Fiorillo E, Mitchell E, Damaskou A, Rak J, Orrù V, Marongiu M, Chapman MS, Vijayabaskar MS, Baxter J, Hardy C, Abascal F, Williams N, Nangalia J, Martincorena I, Campbell PJ, McKinney EF, Cucca F, Gerstung M, Vassiliou GS. Nature 606: 2022 335-342	262
Prolonged persistence of mutagenic DNA lesions in somatic cells. Spencer Chapman M, Mitchell E, Yoshida K, Williams N, Fabre MA, Ranzoni AM, Robinson PS, Kregar LD, Wilk M, Boettcher S, Mahbubani K, Saeb Parsy K, Gowers KHC, Janes SM, Ng SWK, Hoare M, Green AR, Vassiliou GS, Cvejic A, Manz MG, Laurenti E, Martincorena I, Stratton MR, Nangalia J, Coorens THH, Campbell PJ. Nature 638: 2025 729-738	12
Detecting and quantifying clonal selection in somatic stem cells. Körber V, Jakobsen NA, Ansari-Pour N, Moore R, Claudino N, Metzner M, Thielecke E, Esau F, Usukhbayar B, Salazar MA, Newman S, Kendrick BJL, Taylor AH, Afinowi-Luitz R, Gundle R, Watkins B, Wheway K, Beazley D, Dakin SG, Palmer A, Carr AJ, Vyas P, Höfer T. Nat Genet 57: 2025 1718-1729	1
Telomere attrition becomes an instrument for clonal selection in aging hematopoiesis and leukemogenesis. McLoughlin MA, Cheloor Kovilakam S, Dunn WG, Gu M, Tobin J, Pershad Y, Williams N, Leongamornlert D, Dawson K, Bond L, Marando L, Wen S, Wilson R, Valenzano G, Symeonidou V, Rak J, Damaskou A, Gozdecka M, Liu X, Barcena C, Nomdedeu J, Costeas P, Dimitriou ID, Fiorillo E, Orrù V, de Almeida JG, McKerrell T, Cullen M, Mohorianu I, Foukaneli T, Warren AJ, Wong C, Follows G, Godfrey AL, Gudgin E, Cucca F, McKinney E, Baxter EJ, Gerstung M, Mitchell J, Wiseman D, Bick AG, Fabre M, Quiros PM, Nangalia J, Kar S, Vassiliou GS. Nat Genet 57: 2025 2215-2225	2