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The role of the mammalian SWI/SNF chromatin remodeling complex in neuroendocrine prostate cancer

We sought to determine the effects of SMARCA4 and SMARCA2 depletion in prostate cancer cell lines. We performed siRNA-mediated knock-down of SMARCA4 and SMARCA2 in an androgen-sensitive (LNCaP) cell line and in a castration-resistant prostate cancer (CRPC)-adenocarcinoma cell line (22Rv1) and compared global transcriptional alterations using RNA-seq.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005800 Illumina HiSeq 2500 15
EGAD00001006356 Illumina HiSeq 2500 Illumina NovaSeq 6000 Ion Torrent S5 XL 288
Publications Citations
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity.
Nat Commun 11: 2020 5549
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