Chromatin run-on and RNA sequencing of fibrolamellar carcinoma
Fibrolamellar carcinoma (FLC) is a rare, therapeutically intractable liver cancer that disproportionately affects youth. Here we used chromatin run-on sequencing to characterize the enhancer landscape in FLC and RNA sequencing to identify dysregulated genes in FLC.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001005797 | NextSeq 500 | 30 |
Publications | Citations |
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Hotspots of Aberrant Enhancer Activity in Fibrolamellar Carcinoma Reveal Candidate Oncogenic Pathways and Therapeutic Vulnerabilities.
Cell Rep 31: 2020 107509 |
19 |
DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.
PLoS One 17: 2022 e0263829 |
5 |
Multiomic analysis of microRNA-mediated regulation reveals a proliferative axis involving miR-10b in fibrolamellar carcinoma.
JCI Insight 7: 2022 e154743 |
6 |
Chemical, Molecular, and Single-nucleus Analysis Reveal Chondroitin Sulfate Proteoglycan Aberrancy in Fibrolamellar Carcinoma.
Cancer Res Commun 2: 2022 663-678 |
2 |
DNAJB1-PRKACA fusion neoantigens elicit rare endogenous TÂ cell responses that potentiate cell therapy for fibrolamellar carcinoma.
Cell Rep Med 5: 2024 101469 |
0 |
DNAJB1-PRKACA fusion protein-regulated LINC00473 promotes tumor growth and alters mitochondrial fitness in fibrolamellar carcinoma.
PLoS Genet 20: 2024 e1011216 |
1 |