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Imaging metabolic heterogeneity in breast cancer using hyperpolarized 13C-MRI

Higher 13C-lactate labeling was seen in the more aggressive tumors, including all triple negative breast cancers. There was a significant correlation between lactate labeling and expression of the monocarboxylate transporter (MCT1), which mediates tumor cell pyruvate uptake, and a weaker correlation with expression of LDHA, which catalyzes label exchange between the injected pyruvate and the endogenous lactate pool.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005760 Illumina HiSeq 2500 14
EGAD00001008141 Illumina HiSeq 2500 10
Publications Citations
Imaging breast cancer using hyperpolarized carbon-13 MRI.
Proc Natl Acad Sci U S A 117: 2020 2092-2098
101
Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients.
Cancer Res 81: 2021 6004-6017
20