Multiple Sclerosis risk variants regulate gene expression in innate and adaptive immune cells
Each of at least 200 single nucleotide polymorphisms (SNPs) have been confirmed to be associated with individually small increases in the risk of Multiple Sclerosis (MS). A key function that could mediate SNP encoded MS risk is their regulatory effects on gene expression or splicing. Transcriptomic profiling was performed using Affymetrix gene-expression microarrays, using RNA extracted from purified human peripheral blood monocytes, CD4 and CD8 positive lymphocyte cells, B-lymphocyte cells and Natural Killer cells from 73 untreated MS cases and 97 healthy controls. Cis expression quantitative trait locus (eQTL) mapping studies were performed in each cell type separately to characterize MS risk loci associated with gene expression change.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00010001825 | Affymetrix Human Gene_1.0ST array | 140 | |
| EGAD00010001826 | Affymetrix Human Gene_1.0ST array | 123 | |
| EGAD00010001827 | Affymetrix Human Gene_1.0ST array | 131 | |
| EGAD00010001828 | Affymetrix Human Gene_1.0ST array | 124 | |
| EGAD00010001829 | Affymetrix Human Gene_1.0ST array | 146 | |
| EGAD00010001830 | Illumina Immunochip | 170 |
| Publications | Citations |
|---|---|
|
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells.
Life Sci Alliance 3: 2020 e202000650 |
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