Whole genome and whole transcriptome sequencing of patients diagnosed with angiosarcoma.
Angiosarcomas are rare, clinically-aggressive tumors with a predilection for the elderly and immunosuppressed, which has incited suspicion of an oncogenic virus. We studied the metagenomic landscape of angiosarcomas and identified reads mapping to human herpesvirus-7 (HHV-7). Overall, HHV-7 was present in two-thirds of angiosarcomas, particularly in cases with low tumor mutation burden and lacking signatures of ultraviolet-induced DNA damage. Transcriptomic profiling revealed the enrichment of tumor inflammation signatures in HHV7-positive angiosarcomas. In conclusion, we identified a distinct “inflammatory” subtype of angiosarcoma associated with HHV-7.
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
Dataset ID | Description | Technology | Samples |
---|---|---|---|
EGAD00001005366 | HiSeq X Ten Illumina HiSeq 2000 | 31 | |
EGAD00001005367 | Illumina HiSeq 2500 | 18 |
Publications | Citations |
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Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma.
J Clin Invest 130: 2020 5833-5846 |
41 |
Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma.
Commun Biol 6: 2023 461 |
7 |