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A single-cell atlas of human glioma

Although tumor-propagating cells can be derived from glioblastomas (GBMs) of the proneural and mesenchymal subtypes, a glioma stem-like cell (GSC) of the classical subtype has not been identified. It is unclear if mesenchymal GSCs (mGSCs) and/or proneural GSCs (pGSCs) alone are sufficient to generate the spectrum of cellular heterogeneity observed in GBM. This study sheds light on a long-standing debate regarding lineage relationships among GSCs.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005314 Illumina NovaSeq 6000 6
EGAD00001005368 Illumina NovaSeq 6000 5
EGAD00001005369 Illumina NovaSeq 6000 4
EGAD00001005390 Illumina NovaSeq 6000 1
EGAD00001005391 Illumina NovaSeq 6000 -
EGAD00001005392 Illumina NovaSeq 6000 -
EGAD00001005393 Illumina NovaSeq 6000 -
EGAD00001005394 Illumina NovaSeq 6000 -
EGAD00001005395 Illumina NovaSeq 6000 -
EGAD00001005396 Illumina NovaSeq 6000 1
EGAD00001005397 Illumina NovaSeq 6000 -
EGAD00001005398 Illumina NovaSeq 6000 -
EGAD00001005399 Illumina NovaSeq 6000 1
EGAD00001005401 Illumina NovaSeq 6000 1
EGAD00001005402 Illumina NovaSeq 6000 1
EGAD00001005403 Illumina NovaSeq 6000 -
EGAD00001005405 Illumina NovaSeq 6000 -
EGAD00001005406 Illumina NovaSeq 6000 -
EGAD00001005407 Illumina NovaSeq 6000 -
EGAD00001005408 Illumina NovaSeq 6000 -
EGAD00001005409 Illumina NovaSeq 6000 1
EGAD00001005410 Illumina NovaSeq 6000 1
EGAD00001005411 Illumina NovaSeq 6000 -
EGAD00001005412 Illumina NovaSeq 6000 1
EGAD00001005413 Illumina NovaSeq 6000 -
EGAD00001005414 Illumina NovaSeq 6000 -
EGAD00001005415 Illumina NovaSeq 6000 1
EGAD00001005418 Illumina NovaSeq 6000 1
EGAD00001005428 Illumina NovaSeq 6000 -
EGAD00001005429 Illumina NovaSeq 6000 -
EGAD00001005430 Illumina NovaSeq 6000 1
Publications Citations
The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation.
Cancer Discov 9: 2019 1708-1719
162
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states.
Nat Genet 53: 2021 1469-1479
89
Glioblastoma heterogeneity at single cell resolution.
Oncogene 42: 2023 2155-2165
25
Dissecting the tumor microenvironment of epigenetically driven gliomas: Opportunities for single-cell and spatial multiomics.
Neurooncol Adv 5: 2023 vdad101
0